Scientist, Renal Cell Biology & Physiology (Epithelial and Endothelial Cell Biologist)
About The Position
We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation. Our public benefit purpose is to provide a brighter future for patients through the development of novel pharmaceutical therapies; and technologies that expand the availability of transplantable organs. United Therapeutics (Nasdaq: UTHR ) seeks to travel down the corridors of indifference to develop treatments for rare, deadly diseases. We were founded in 1996 by a family seeking a cure for their daughter’s pulmonary arterial hypertension ( PAH ). Today, we have six FDA-approved therapies that treat PAH, pulmonary hypertension associated with interstitial lung disease ( PH-ILD ) and neuroblastoma, a rare pediatric cancer. Our near-term pipeline seeks to develop additional therapies for PAH and pulmonary fibrosis ( PF ). The cure for end-stage life-threatening diseases like PAH, PH-ILD, PF, and many others is an organ transplant, but only a small percentage of donated organs are available to address the vast need. For this reason, we are working to create manufactured organs to address the shortage of kidneys, hearts, lungs, and livers available for transplant. We believe an unlimited supply of tolerable, transplantable organs will eliminate the transplant waiting list and cure end-stage organ diseases for which transplant is not currently an option. Millions worldwide are living with chronic kidney disease or diabetes. Management and maintenance therapies are ongoing, expensive, and often undermine the person’s quality of life. Their only hope for a cure is an kidney transplant. Unfortunately, the shortage of available kidneys causes patients to spend an average of 5 or more years on the waitlist, and many die before receiving surgery. At IVIVA, we are working to transform the status quo by developing fully implantable bioartificial kidneys. Our goal is to develop a cure that can allows patients with kidney dysfunction to lead a normal life There has never been a more exciting time to join IVIVA, a United Therapeutics company. This position offers someone the opportunity of a lifetime – to see a product into something real, an opportunity to create a human kidney equivalent and save lives on a scale before unknown. This position is seeking a endothelial and/or epithelial cell biologist and enthusiast to advance the maturity and function of iPS derived renal cells in 2D and 3D systems. This position plans, conducts, and supports experiments to develop, manufacture, and evaluate cell-based therapeutics for the treatment of end-stage renal disease. Does this sound like you? Apply below and we look forward to chatting with you!
Requirements
- Master’s Degree in cell and molecular biology, developmental biology , physiology, or related field with 5 + years of academic and/or industry experience in physiology, developmental biology, tissue engineering, or related fields OR Doctor of Philosophy (PhD) in cell and molecular biology, or related field (preferred) with 2 years academic and/or industry experience in physiology, developmental biology, tissue engineering, or related fields
- Demonstrated expertise designing, planning, and executing experiments using cell and molecular biology tools
- Experience with epithelial or endothelial cell biology
Nice To Haves
- Doctor of Philosophy (PhD) in cell and molecular biology, or related field (preferred) with 2 years academic and/or industry experience in physiology, developmental biology, tissue engineering, or related fields
- Knowledge of kidney and/or pancreas biology and physiology
Responsibilities
- Perform isolation, characterization, and maturation of human primary renal cells
- Support the derivation, isolation, characterization, and maturation of human iPSC derived renal cells
- Support the scaling manufacturing protocols of iPSC derived renal cells
- Apply developmental biology processes to direct cell fate decisions and morphogenesis of primary and iPSC derived cells and three-dimensional constructs
- Perform physiologic characterization of primary and iPSC derived renal cells in 2D and 3D tissue models
- Integrate multiple renal cell types in 3D structures capable of higher-level functions such as filtration and reabsorption
- Actively contribute to interactions with academic, industry, and regulatory partners and collaborators
- All other duties as required
Benefits
- Eligible employees may participate in the Company’s comprehensive benefits suite of programs, including medical / dental / vision / prescription coverage, employee wellness resources, savings plans (401k and ESPP), paid time off & paid parental leave benefits, disability benefits, and more.
- For additional information on Company benefits, please visit https://www.unither.com/careers/benefits-and-amenities
- Eligible employees may participate in the Company’s comprehensive benefits suite of programs, including medical / dental / vision / prescription coverage, employee wellness resources, savings plans (401k and ESPP), paid time off & paid parental leave benefits, disability benefits, and more.
- For additional information on Company benefits, please visit https://www.unither.com/careers/benefits-and-amenities
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Number of Employees
1,001-5,000 employees
