Scientist, Protein Production and Characterization
About The Position
AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science. We are seeking a highly motivated and skilled Scientist to join our Protein Sciences team and contribute to both day-to-day operations and the advancement of Protein Science workflows. This position will focus on the design, optimization, and execution of transient transfection processes at various scales for antibody and protein production in mammalian expression systems. The successful candidate will leverage expertise in biophysical characterization and biochemical modification to evaluate key protein attributes. This position will report to the Associate Director of Protein Sciences and work closely with scientists in the Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management teams. The ideal candidate will drive innovation through process refinement, high-throughput automation, and growing proficiency of chemical conjugation techniques. This role offers the opportunity to work in a fast-paced, collaborative research environment, where creative solutions and a strong scientific approach are key to success.
Requirements
- Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or a related field with a minimum of 2 years of industry experience or MS with minimum of 6 years of direct industry experience is required
- Proven hands-on experience with multiple mammalian expression platforms is required
- Proficiency with AKTA instrumentation, and a broad range of purification techniques, including affinity chromatography, ion exchange, HIC, and SEC, as well as standard protein QC methodologies is required
- Experience with therapeutic antibody developability assessment is highly desirable
- Strong analytical, troubleshooting, and communication skills with exceptional attention to detail
- Motivated self-starter with excellent organization, teamwork, and a passion for scientific innovation
Responsibilities
- Independently design, plan, and execute transient transfection workflows for antibody and protein production across various mammalian expression systems
- Develop, design, and optimize protein purification methods to enhance throughput, quality, and efficiency, as required
- Lead developability assessment studies by designing and conducting analytical experiments to evaluate protein stability, purity, and key biophysical characteristics
- Support production of complex construct design strategies (e.g VLPs, nanodiscs etc.), to enable immunization antibody discovery campaigns against challenging targets
- Drive implementation of automated high throughput processes to support protein production workflows using Bravo, and other robotic systems
- Maintain meticulous experimental records using electronic notebook (Benchling), and communicate results clearly through written reports and presentations to support project progression and scientific decision-making
- Contribute innovative ideas and collaborate effectively across teams to foster research excellence and ensure project success in a fast-paced environment
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
11-50 employees
