Scientist, Pharmacokinetics

MSD • Upper Gwynedd Township, PA

2d • Hybrid

About The Position

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our company in West Point, Pennsylvania, is seeking a highly skilled and motivated Scientist to join the Transporter Science Group. The Transporter Science group is a center of excellence to design, execute, and integrate transporter related in vitro and preclinical studies to support our company's Portfolio through all stages of drug discovery and development. We are also driving cutting edge ADME-transporter science via development and implementation of novel in vitro and preclinical models, as well as translational approaches to enhance our capabilities to quantitatively predict the roles of transporters on ADME, drug-drug interactions (DDIs), efficacy, and toxicity of drugs in a diversified portfolio that spans various therapeutic areas and modalities. In this position, candidates will be responsible to generate transporter related in vitro data to support discovery and development programs. Candidates will also have the opportunity to work closely with other scientists across the network to advance our scientific strategy via developing and implementing novel tools/emerging technologies. Successful candidates should have a passion for generating high quality data for use by project teams across a range of therapeutic areas and must be able to work independently with a range of in vitro assay systems. In addition, candidates will be conducting experiments using automated liquid handlers and other sophisticated scientific instrumentation. Candidates must have excellent written and verbal communications and experience working in a team environment.

Requirements

• A master’s or bachelor’s degree in a relevant field (e.g. Biochemistry, Biology, Biotechnology, Molecular and Cell Biology, Pharmacology; Pharmaceutical Sciences) with 1-3+ years of relevant laboratory experience
• Demonstrated ability to design, perform and interpret in vitro studies generated in cell lines, hepatocytes or subcellular fractions per established protocols
• Cell culture, including aseptic techniques and maintenance of recombinant cell lines and primary cells
• Ability to work independently and effectively to develop and validate new assays with some technical and strategic supervision
• Proficiency in data handling software such as Excel and Graphpad, ability to document results accurately and generate reports to be shared with internal partners or regulatory agencies
• Strong communication and collaboration skills with flexibility to operate in a team environment
• Autonomy, attention to details, critical thinking, and growth mindset

Nice To Haves

• Hands-on experience and knowledge of transporter-related in vitro studies (eg, cellular uptake studies, transporter inhibition assays)
• Basic understanding of quantitation using radiometric or LC/MS-based methods
• Experience operating liquid handlers and working with assay automation
• Experience working in the pharmaceutical industry or in a contract research organization (CRO)

Responsibilities

• Generate transporter related in vitro data to support discovery and development programs.
• Work closely with other scientists across the network to advance our scientific strategy via developing and implementing novel tools/emerging technologies.
• Generating high quality data for use by project teams across a range of therapeutic areas.
• Work independently with a range of in vitro assay systems.
• Conducting experiments using automated liquid handlers and other sophisticated scientific instrumentation.

Benefits

• The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
• We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days.
• More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level