Scientist, Non-Viral Gene Editing Platforms

Bristol Myers Squibb • Seattle, WA

15h • Onsite

About The Position

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes

Requirements

• Bachelor’s Degree 5+ years of academic and / or industry experience
• Or Master’s Degree 3+ years of academic and / or industry experience
• Or Ph.D. or equivalent advanced degree in the Life Sciences

Nice To Haves

• Hands-on experience with gene editing technologies (CRISPR/Prime editing preferred)
• Experience with in vivo non-viral gene delivery platforms (including non-cell therapy applications)
• Strong knowledge of molecular biology and prior experience with DNA design tools such as Benchling, Geneious, etc.
• Experience culturing T cells including aseptic technique, T cell activation, and maintenance of primary cell cultures
• Experience with multi-color flow cytometry including complex panel design and multi-parameter data analysis (FlowJo)
• Ability to effectively multi-task, independently organize time, and can develop timelines and deliver results accordingly
• Demonstrated ability to work within a team and thrive in a fast-paced and ever-changing environment
• Detail oriented with excellent verbal and written communication skills and careful documentation (prior ELN experience a plus)

Responsibilities

• Spends a majority of the time working in the lab independently executing experiments and recording detailed ELN entries
• Works diligently within the team to optimize base ex vivo editing platform and implement new technologies for continuous improvement and next-gen in vivo platform development (e.g., lipid nanoparticles)
• Routinely generates CAR-T cells including non-viral gene editing, expansion, and cryopreservation of engineered cells
• Thoroughly characterizes engineered CAR-T cells including phenotypic analysis via flow cytometry, in vitro cytotoxicity assays (e.g., Incucyte), and genomic DNA extraction for downstream molecular analysis
• Independently analyses and interprets experimental data, experience with large and complex datasets a plus
• Actively troubleshoots routine problems and initiatives related to continuous improvement or development of new approaches / technologies
• Proactively communicates and aligns with team members to achieve results and support cross-functional activities
• Generates key data to support decisions that impact the larger team
• Presents findings in multidisciplinary meetings, logically explaining complex scientific concepts and clearly highlighting key messages
• May represent department or team on program/project team or sub-team

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree