Scientist - LC-MS Bioanalytical

Amgen • Thousand Oaks, CA

2d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist - LC-MS Bioanalytical What you will do Let’s do this. Let’s change the world. In this vital role, you will support the design, development, validation, and implementation of robust LC-MS/MS bioanalytical methods for a wide range of therapeutic modalities—including small molecules, oligonucleotides, proteins, and other complex molecular entities—to enable GLP preclinical and regulated clinical studies. Given the scope of projects, the role will involve multidisciplinary interactions with scientists across research and development at Amgen. The position is lab-based, and has significant emphasis on data management/fidelity, report generation, effective time management, communication, and data presentation.

Requirements

• Doctorate degree PhD or PharmD or MD [and relevant post-doc where applicable] and 1-3 years of relevant industrial or postdoctoral experience Or Master’s degree and 5 years of relevant industrial/technical experience Or Bachelor’s degree and 7 years of relevant industrial/technical experience

Nice To Haves

• Prior experience in CRO or pharma/biotech strongly desired
• Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms as well as HRMS
• Experience with an array of analytical technologies that can accelerate bioanalysis inclusive of automation and/or micro-sampling
• Prior GLP and GCP experience.
• Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, serum, tissues, cerebrospinal fluid) and employing diverse sample preparation techniques (e.g., SPE, LLE, immunocapture) to support analysis of different therapeutic modalities, including small and large molecules by LC-MS.
• Prior experience in bioanalytical (regulated) assay execution and transfer to CROs
• Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines.
• Demonstrated ability to resolve scientific challenges efficiently and prioritize effectively
• Excellent scientific problem-solving skills
• Excellent project and time management abilities
• Ability to work collaboratively with internal and external stakeholders
• Supervisory and mentoring experience in a lab-based setting

Responsibilities

• Perform quantitative bioanalytical experiments and organize data and results, including planning and running LC-MS/MS bioanalysis and preparing and analyzing biological samples
• Develop and implement LC-MS/MS bioanalytical methods with quick turnaround times.
• Conduct small and large molecule bioanalysis in non-clinical and clinical samples from various matrices (plasma, urine, CSF, tissues).
• Perform biological sample extraction using protein crash (PPT), SPE, LLE, and/or affinity capture methodologies.
• Generate complete, accurate, and concise documentation using electronic systems and laboratory notebook
• Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines.
• Author study reports, standard operating procedures, analytical methods, memos, and other regulatory-compliant documents.
• Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings.
• Comply with safety guidelines and site-specific procedures which include but is not limited to the completion of training on assigned tasks, maintenance of training records, laboratory documentation, and following detailed SOPs and other written procedures.
• Perform general laboratory housekeeping activities and operational support as needed, including QC of reports.

Benefits

• In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees