Scientist, Immunogenicity Assay Development (Contractor)

Arcellx • Rockville, MD

10h

About The Position

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.
Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.
Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.
Arcellx Core Values
Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work.
Think ‘we’ before ‘me’: We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what’s right.
The “Fine Print”
As a contractor on our Cell Bio team, you will...

Requirements

• BS and 5+ years or MS and 2+ years of assay development experience within the pharmaceutical industry setting.
• Expertise in cell culture with a focus on manipulating PBMCs and T-cells, including activation, purification, and cryopreservation.
• Working knowledge of immunology and a familiarity with markers of activation for phenotyping of T-cells by flow cytometry.
• Expertise in flow cytometry panel design and optimization.
• Expertise in immune cell assays including multiparameter flow cytometry and in vitro assays to determine T-cell activation or proliferation (e.g., BrdU incorporation). Preferably experience with BD instruments or Cytek Aurora for flow cytometry.
• Proficient in common software, including GraphPad Prism, FlowJo, and Office suite.
• Commitment to ethical scientific investigations and rigorous experimental methods.
• Ability and desire to multitask and function in a fast-paced environment.
• Interpersonal skills that promote a collaborative and productive lab environment.
• Effective and efficient written and oral communication skills.

Responsibilities

• Build an in vitro immunogenicity assay using HLA-Typed PBMCs, assessing T-cell activation and proliferation as measured through flow cytometry. Through the use of clinical benchmarks and in-house data, build a relative risk assessment for clinical immunogenicity based on these in vitro.
• Careful documentation of assay development, including drafting SOPs and electronic lab notebook entries.
• Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions.
• Design and execute experiments independently with minimal supervision, as well as effectively plan and organize work activities and prioritize task completion.
• Other duties as assigned.

What This Job Offers

• Career Level: Mid Level