Scientist II - Oligo Synthesis

Roche • Pleasanton, CA

1d

About The Position

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position As a Scientist II in the Oligo Manufacturing Group, you will be manufacturing oligonucleotides on DNA synthesizers so we can ensure the consistent, high-quality production required to meet the increasing demand for oligonucleotides in our R&D pipelines The Opportunity Manufacturing oligonucleotides on DNA Synthesizers using established procedures and technical understanding, including gel purification and ensuring accuracy, quality, and timely results while maintaining lab supplies and instruments. Coordinating with the oligo purification group for smooth handoffs, processing incoming oligo orders, interfacing with vendors, and prioritizing orders for in-house manufacturing or external vendors as required. Preparing experimental results, reviewing conclusions with supervisors/project leads, and keeping them informed about project status, significant findings, and critical issues. Following internal safety guidelines and external regulatory standards (e.g., OSHA) while participating in lab maintenance, lab safety, and ISO/QSR implementation. Setting up, maintaining, and troubleshooting oligo synthesis instruments while prioritizing, scheduling, and batching oligo syntheses for efficient, timely, and cost-effective production, including handling RUSH or repeat orders. Assisting with routine analyses (HPLC, LCMS, UV spectral) on oligos, maintaining laboratory/reagent supplies to avoid manufacturing downtime, and supporting others in the manufacturing lab as needed. Ensuring thorough and timely documentation of synthesis records, oligo orders, and lab data in notebooks and electronic systems, preparing data for analyses, reports, or presentations. Who You Are You have a Bachelor's degree in Chemistry, Biochemistry, Biological/Life Sciences, or related field, and a minimum of 2 years of related experience, A Master's and 4-5 years of experience in oligonucleotide manufacturing is preferred Equivalent combination of education and work experience Relocation Benefits are not offered for this job posting. The expected salary range for this position based on California is 66,900 - 109 825 USD Annually. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. We are proud of who we are, what we do, and how we do it. We are many, working as one across functions, across companies, and across the world. We are Roche.

Requirements

• Bachelor's degree in Chemistry, Biochemistry, Biological/Life Sciences, or related field, and a minimum of 2 years of related experience
• Equivalent combination of education and work experience

Nice To Haves

• A Master's and 4-5 years of experience in oligonucleotide manufacturing is preferred

Responsibilities

• Manufacturing oligonucleotides on DNA Synthesizers using established procedures and technical understanding, including gel purification and ensuring accuracy, quality, and timely results while maintaining lab supplies and instruments.
• Coordinating with the oligo purification group for smooth handoffs, processing incoming oligo orders, interfacing with vendors, and prioritizing orders for in-house manufacturing or external vendors as required.
• Preparing experimental results, reviewing conclusions with supervisors/project leads, and keeping them informed about project status, significant findings, and critical issues.
• Following internal safety guidelines and external regulatory standards (e.g., OSHA) while participating in lab maintenance, lab safety, and ISO/QSR implementation.
• Setting up, maintaining, and troubleshooting oligo synthesis instruments while prioritizing, scheduling, and batching oligo syntheses for efficient, timely, and cost-effective production, including handling RUSH or repeat orders.
• Assisting with routine analyses (HPLC, LCMS, UV spectral) on oligos, maintaining laboratory/reagent supplies to avoid manufacturing downtime, and supporting others in the manufacturing lab as needed.
• Ensuring thorough and timely documentation of synthesis records, oligo orders, and lab data in notebooks and electronic systems, preparing data for analyses, reports, or presentations.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees