Scientist I, Oligonucleotide Chemistry

Tessera Therapeutics•Somerville, MA

16d•$109,000 - $124,000

About The Position

Your experience includes… BS/MS/PhD in Chemistry, Biochemistry, Chemical Engineering, or related field with 8+ years (BS) or 6+ years (MS) or 0-2 years (PhD) of relevant industry experience Excellent knowledge of upstream and downstream processing of oligonucleotides Must have experience with Äkta100 oligonucleotide synthesizer Experience with Mermade192 and Mermade12 synthesizers are a plus Experienced with HPLC purification and analytics of guide RNA preferred Experienced with enzymatic ligation techniques is a plus Experience using ELNs to document experimental results is a plus You are interested in… Developing processes and implementing strategies for internal production of guide RNA to support platform research and pre-clinical activities Optimizing synthetic reactions and purification methods of drug candidates to ensure scalable and cost-effective processes for oligonucleotide manufacturing Working in collaboration with the Internal Manufacturing team during process transfer Participate in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing Supporting the CMC teams management of external vendors About you: You are a skilled, tenacious, and self-motivated individual capable of developing robust processes for synthesizing and purifying complex oligonucleotides. You can operate in a fast-paced environment, troubleshoot instruments, reduce workflow inefficiencies, and document operations independently as well as part of a team. You are experienced with, and can independently operate, a Cytiva Äkta100 to synthesize oligonucleotides. You are familiar with standard cleavage and deprotection procedures as well as TFF operation. You are equipped with strong communication skills, which will be pertinent for presenting data internally and cross-functionally. You enjoy overcoming challenges in collaboration with colleagues. Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.

Requirements

BS/MS/PhD in Chemistry, Biochemistry, Chemical Engineering, or related field with 8+ years (BS) or 6+ years (MS) or 0-2 years (PhD) of relevant industry experience
Excellent knowledge of upstream and downstream processing of oligonucleotides
Must have experience with Äkta100 oligonucleotide synthesizer
skilled, tenacious, and self-motivated individual capable of developing robust processes for synthesizing and purifying complex oligonucleotides
can operate in a fast-paced environment, troubleshoot instruments, reduce workflow inefficiencies, and document operations independently as well as part of a team
experienced with, and can independently operate, a Cytiva Äkta100 to synthesize oligonucleotides
familiar with standard cleavage and deprotection procedures as well as TFF operation
equipped with strong communication skills, which will be pertinent for presenting data internally and cross-functionally
enjoy overcoming challenges in collaboration with colleagues

Nice To Haves

Experience with Mermade192 and Mermade12 synthesizers are a plus
Experienced with HPLC purification and analytics of guide RNA preferred
Experienced with enzymatic ligation techniques is a plus
Experience using ELNs to document experimental results is a plus

Responsibilities

Developing processes and implementing strategies for internal production of guide RNA to support platform research and pre-clinical activities
Optimizing synthetic reactions and purification methods of drug candidates to ensure scalable and cost-effective processes for oligonucleotide manufacturing
Working in collaboration with the Internal Manufacturing team during process transfer
Participate in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing
Supporting the CMC teams management of external vendors