SCIENTIST, FORMULATION AND DP DEVELOPMENT

Sutro Biopharma • South San Francisco, CA

1d • $129,000 - $150,000

About The Position

Sutro Biopharma, Inc. is looking for a technical leader who will report to the Executive Director of Formulation and DP Development. You will be working to develop new compositions for biologic and conjugated molecules and DP manufacturing processes to advance Sutro pipeline and enhance our internal and collaborative product development initiatives in a fast-paced environment.

Requirements

• BS/MS (6-8+ years) or PhD (1-6+ years) of experience in scientific discipline (Pharmaceutical Sciences, Chemistry, Chemical Engineering, Biomedical Engineering, or related discipline) and demonstrated scientific creativity and contributions
• Hands-on experience and proficiency with pilot scale or commercial lyophilizers, lyo cycle development/optimization, knowledge of software
• Solid technical skills and experience in pre-formulation screening studies, biophysical/ biochemical characterization of proteins, analytical method development and protein/ antibody/ADC product development is essential
• Demonstrated ability to design experiments and routinely generate new ideas and original research. High level of scientific initiative and independence. May undertake collaborations with other disciplines. Highly autonomous requiring minimal supervision from manager.
• Analytical instrumentation such as chromatographic (HPLC, UPLC, column chromatography), visible and subvisible particle analysis, capillary electrophoresis and/or biophysical techniques (UV-vis, MALS/DLS, DSC, CD, FTIR, AUC, Fluorescence spectroscopy) for protein characterization are highly desirable.
• Able to cooperate effectively with cross functional teams, such as up and down stream process development, manufacturing and quality. Ability to quickly adapt to changes in project direction.
• Working knowledge of cGMP and relevant drug product development guidelines and regulations
• Flexibility to work on multiple projects between departments in a fast-paced environment is essential.
• Excellent oral and written communication skills and being detailed oriented are important attributes.

Responsibilities

• The candidate we are seeking will work within our Formulation and DP Development team to participate in formulation and DP development for phase appropriate liquid and lyophilized formulations for intermediates, drug substance and drug products.
• The successful candidate will participate in activities in technology transfer to CMO’s.
• The position is expected to design, execute, document formulation and stability studies and other experiments to support the robustness and validity of final formulation and lyo cycle parameters.
• The position will utilize/implement fit-for-purpose analytical methods for biophysical characterization, formulation and process development and stability testing.
• This position is expected to communicate experimental data both verbally at group, department and cross functional meetings and through written documents and reports that may be included in regulatory filings.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree