Scientist, Developmental Phenotype Engineer

Colossal Biosciences•Dallas, TX

1d•Onsite

About The Position

The Scientist will focus on genotype-to-phenotype (G2P) engineering design, testing, and interpretation of biological systems that connect genetic variation to observable traits. Leveraging their expertise in cellular biology, in vivo systems, and developmental biology, they will work closely with bioinformaticians to identify phenotype-relevant genetic pathways and variants and test the effect of those variants in animal models, embryonic tissue, and cell models. This role involves a balance of hands-on experimental work and strategic oversight, with shared responsibility alongside the manager for G2P validation efforts. This position is based on-site in Dallas, TX. Relocation assistance is available

Requirements

Mandatory, hands-on experience with in vivo models.
Excellent track record of scientific ownership, having been the primary driver of a research project.
Hands-on experience with research in associating genomic and/or epigenomic function with a phenotype of interest.
Demonstrated success in establishing any causal link between genotype and phenotype or iterate any gene function, as a primary project stakeholder.
Experience operating large-scale genetic screening platforms (e.g. CRISPR screen, MPRA), in vivo or in vitro.
Analytical and creative thinker with excellent problem-solving skills.
Ability to clearly document, interpret, and communicate complex biological findings.
Practiced interpersonal and critical thinking skills.
Strong collaboration skills and commitment to team-based science.
Strong working knowledge of research methodology and study design; hypothesis testing; qualitative and quantitative data interpretation and application.
Ph.D. in Biology, Developmental Biology, Genetics, Functional Genomics, Molecular Biology, or related field.
1 or more years of industry experience (or equivalent postdoctoral experience).

Responsibilities

Design and execute experiments to characterize G2P relationships in vivo (organismal) and/or in vitro (cellular) systems
Contribute to both high-throughput screening assays and hypothesis-driven experimental studies
Collaborate cross-functionally to iterate between computational predictions and experimental validation
Serve as a key scientific contributor and stakeholder in advancing G2P programs
Strategically oversee experimental animal models generated by the team.
Stage, sample, and manipulate fetal and embryonic tissues and structures.
Work closely with the bioinformatics team to identify genetic variants of interest.
Contribute to, and be responsible for, documentation, reports, presentations and publications associated with work.
Develop and optimize wet-lab multi-omics workflows, including bulk, single-cell, and spatial gene expression and chromatin conformation, state, and accessibility assays.
Process, image, and analyze embryos of various stages using techniques such as fluorescent microscopy, whole mount skeletal staining and morphometrics.