Scientist - Conjugation and Purification

AstraZeneca • Gaithersburg, MD

1d

About The Position

At AstraZeneca, we're embarking on an exciting new frontier in medical science – the quest to extend human health span. Our newly formed Aging Research Group is at the forefront of this groundbreaking initiative, aiming to develop innovative therapeutics that not only add years to life but life to years. In this role, you will be part of a team of highly skilled and passionate individuals responsible for innovating and generating the best in class of antibody drug conjugates for various therapeutic areas. We are seeking a highly motivated conjugation scientist with a preferred background in drug discovery. Exciting opportunity to learn and contribute to multi-disciplinary drug development.

Requirements

• Bachelor's or Master's degree in biotechnology, Pharmaceuticals Sciences, Chemical Biology, Biochemistry, Chemistry, or other relevant scientific field with 3+ years (BS degree) or 0-1 years (MS degree) of relevant experience.
• Hands-on experience and knowledge of protein purification using HIC, IEX, SEC and affinity chromatography. Experience with GE AKTA FPLC preferred.
• Working knowledge of characterization using analytical techniques like Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, etc.
• Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines
• Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset and maintains a detailed laboratory notebook

Nice To Haves

• Demonstrated hands-on experience in the generation of RC and ADC.
• Experience with radiochemistry and related assays.
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management.

Responsibilities

• Conjugation, purification and characterization of precursors for radio-conjugates (RC) and ADC using multiple validated methodologies
• Development and optimization of novel conjugation methodologies to improve RC and ADC properties
• Radiolabeling of RC for in vitro and biodistribution evaluations
• Collaborate and work with a diverse group of scientists across multiple therapeutic areas, chemistry, and process development to ensure timely progress in research projects and drive technological innovations
• Partner with colleagues on laboratory maintenance, including maintenance of equipment and lab safety.

Benefits

• qualified retirement programs
• paid time off (i.e., vacation, holiday, and leaves)
• health, dental, and vision coverage in accordance with the terms of the applicable plans

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 5,001-10,000 employees