Scientist, Biology

Gilead Sciences•Foster City, CA

23h

About The Position

At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. Position Overview: We are seeking a highly motivated and creative Research Scientist to join the Discovery Sciences and Technologies (DST) Department and contribute to our biophysics capabilities to enable the identification and nomination of small molecule and biologics drug candidates across all therapeutic areas at Gilead. DST Department members are responsible for the design and execution of rigorous, quantitative, in vitro biochemical, biophysical, and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate. The successful candidate will be an integral member of the DST research team and work closely with various Research functions such as medicinal chemistry, structural biology, and protein therapeutics to advance transformational therapies into clinical development for patients. Gilead is a highly matrixed organization and the ability to work effectively across diverse functional groups and therapeutic areas is a key attribute for this role.

Requirements

Bachelor's Degree and 6 years experience OR Master's Degree and 4 years experience OR PhD /PharmD

Nice To Haves

Ph.D. with a minimum of 2 years of experience, or an M.Sc. with 5-7 years of experience in in biochemistry, enzymology, biophysics or a related scientific discipline and direct experience in assay development and/or inhibitor mechanism of action studies.
Background in classical enzymology and biophysics (SPR ITC, MST, KinExA), including steady-state and pre-steady-state kinetics, thermodynamics, and reaction mechanism
Expertise in a broad range of assay formats including activity assays, competitive binding assays, and direct binding assays to identify and characterize small molecules and biologics.
Practical experience applying mass spec approaches for drug discovery and experience studying covalent and degrader small molecule modalities would be advantageous.
Strong analytical skills and a solid understanding of rate equations and data fitting statistics
Excellent verbal and written communication skills to disseminate information to direct colleagues and broad audiences
Track record of productivity in diverse work environments
The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to answer complex scientific questions using a variety of biophysical techniques e.g. mass spectrometry
Experience with automation is a definite plus
Must be detail-orientated and extremely well-organized
Strong interpersonal and communication skills, with enthusiasm for working in a driven environment characterized by rigorous scientific and innovative thinking
Excellent written and oral organizational skills

Responsibilities

Apply steady-state and pre-steady-state kinetic assays to characterize enzyme targets and inhibitor mechanism of action
Experience with mass spectrometry-based and biosensor approaches for lead ID characterization of novel and traditional drug modalities including PROTACs, molecular glues and covalent inhibitors
Strong technical background in cellular assay development and signaling pathways
Must be both a critical and creative thinker and be able to apply an advanced level of understanding and analytical skills to interpret data and draw conclusions within the broader context of project goals
Able to troubleshoot and optimize assays as needed, identifying, and applying novel techniques or proactively seeking out solutions
Perform critical experiments to enable hit identification and lead optimization across therapeutic modalities
Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels
Evaluate and implement new technologies to support advancement of internal programs and core group functions
Contribute to several projects at any given time, work successfully in a cross-functional team environment, and communicate clearly both verbally and in writing to a variety of audiences

Benefits

This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package.
Benefits include company-sponsored medical, dental, vision, and life insurance plans.
For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing
Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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