Scientist, Biologics Cell Line Development

Asimov • Boston, MA

13d • Onsite

About The Position

Our mission at Asimov is to radically advance humankind's ability to design living
systems. We're developing a mammalian synthetic biology platform––from cells to
software––to enable biotechnologies with outsized impact, with an initial focus on
gene therapies, cell therapies, and protein therapeutics.

We are seeking a Scientist, Biologics Cell Line Development to join our team in
Boston, MA and help push the boundaries of biotherapeutic cell line development.
This role is for a hands-on technical leader on our team, who will drive CHO-based
cell line development for biologic therapeutics while helping advance scalable,
automated and data-driven CLD workflows. You will design and execute complex
experimental strategies, improve CLD workflows and systems, coordinate project
efforts, and mentor junior scientists.

The successful candidate will also work closely with Asimov’s synthetic biology and
process development teams. This is a unique opportunity to work at a nimble,
forward-thinking synthetic biology startup and help build the future of biological
engineering.
You’ll perform all aspects of CHO cell line engineering for production of
therapeutic candidates including transfection, cloning, characterization, and
cell banking using state-of-the-art equipment.
Design, execute, and optimize high-throughput and/or automated CLD
workflows, including integration of new tools, instrumentation, or data
streams.
You’ll drive innovation through the development of improved host cells,
expression vectors and cell line development workflows.
You’ll identify emerging practices for biologics cell line development and
manufacturing to shape scientific strategies and develop improved CHO
expression systems.
You’ll represent the cell line development team on cross-functional projects,
making decisions for cell line activities and effectively communicating
results, progress and plans.

Requirements

• You have a Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field.
• You have experience performing biological drug production, protein analytics and/or process development
• We’re looking for someone with 1-3 years of hands-on industry experience performing CHO cell line development in support of biologic (mAb & bsAb) therapies.
• You’re a creative problem solver and get excited about the opportunity to drive the creation of industry-disruptive technology.
• Experience working with automation, high-throughput screening, or scaled CLD workflows, such as liquid handling systems, automated cloning/screening platforms, or bioreactor systems.

Nice To Haves

• Familiar with ambr15 and or ambr250 systems.
• Experience working with a global customer base

Responsibilities

• Perform all aspects of CHO cell line engineering for production of therapeutic candidates including transfection, cloning, characterization, and cell banking using state-of-the-art equipment.
• Design, execute, and optimize high-throughput and/or automated CLD workflows, including integration of new tools, instrumentation, or data streams.
• Drive innovation through the development of improved host cells, expression vectors and cell line development workflows.
• Identify emerging practices for biologics cell line development and manufacturing to shape scientific strategies and develop improved CHO expression systems.
• Represent the cell line development team on cross-functional projects, making decisions for cell line activities and effectively communicating results, progress and plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree