Scientist , Antibody Engineering

Twist Bioscience•South San Francisco, CA

About The Position

We are seeking an outstanding, innovative, and creative Scientist to join our antibody discovery effort. This Scientist will play multiple roles within the Pharma group and will work within a team responsible for antibody discovery utilizing a number of in vitro display technologies, e.g. phage display, ribosome display, and yeast display.

Requirements

PhD or equivalent in Biochemistry, Molecular Biology, Protein Engineering or related field; MS / MA with 2-5 years industry experience.
Extensive skills in molecular biology and antibody engineering methods/best practices and applications.
Experience with at least one of the antibody display technologies, such as phage, ribosome or yeast required.
Extensive use of scientific databases and applications for data management and data analysis, including, but not limited to, DNA sequence analysis of antibody genes.
Experience in antibody or protein characterization.
Hands-on expertise with automated platforms.
Excellent written and verbal communication skills are required.

Nice To Haves

D. or M.S. with antibody engineering experience
Postdoctoral experience preferred but not required
Experience with library design and construction for both discovery and antibody optimization
Experience with cytometry and FACS is preferred
Experience with SPR or BLI is preferred
Desire to work in a dynamic start-up environment is essential
Ability to multitask and thrive in a fast-paced and challenging environment
Work cross functionally within and across the department effectively as a team-player
Excellent problem-solving capabilities

Responsibilities

Lead the generation of therapeutic and reagent antibodies by phage, ribosome or yeast display technologies to meet design criteria set by external and internal stakeholders.
Lead biopharma programs to maintain project timeline and report progress regularly to the project team and external stakeholders.
Contribute to display library design and construction using public and in-house generated data.
Help train and supervise research associates.
Perform library construction, selection and screening to identify desirable antibodies against diverse targets, including cell expression targets.
Apply Ab engineering tools and expertise to design and execute antibody humanization and optimization.
Have solid knowledge in antibody phage display or other related display technology.
Perform high throughput primary binding assays with automation.
Work collaboratively under aggressive timelines.