Advisor - Antibody Engineering - BioTDR
About The Position
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. We are seeking a highly motivated and experienced Protein Engineer to join our BioTDR team at Eli Lilly and Company. This role will be responsible for the design, generation, optimization and novel delivery technologies of therapeutic antibodies to support our innovative drug discovery pipeline.
Requirements
- Ph.D. in Molecular Biology, Immunology, Biochemistry, or a related field with 2+ years of relevant experience in protein engineering within an industry setting, or an M.S. with 5+ years of relevant experience.
Nice To Haves
- Demonstrated expertise in protein design, generation, and engineering techniques, including molecular cloning, mutagenesis, and library construction.
- Proficiency with various antibody display technologies (e.g., phage display, yeast display).
- Strong hands-on experience with antibody characterization techniques (e.g., ELISA, SPR/BLI, flow cytometry).
- Experience with viral delivery methods a plus.
- Excellent analytical, problem-solving, and critical thinking skills.
- Ability to work independently and collaboratively in a fast-paced, multidisciplinary environment.
- Strong oral and written communication skills with the ability to effectively present scientific data.
Responsibilities
- Design and execute strategies for the generation and engineering of therapeutic antibodies using various technologies (e.g., rational design, phage display, yeast display) and molecular biology techniques.
- Perform antibody humanization, affinity maturation, and developability optimization using rational design and high-throughput screening methods.
- Support the development of antibodies for the delivery through genetic medicines.
- Characterize antibody binding, specificity, and functional activity using biochemical and cell-based assays (e.g., ELISA, SPR, flow cytometry).
- Collaborate closely with project teams, including discovery biologists, protein scientists, genetic medicine, in vivo pharmacologists, to advance therapeutic programs.
- Analyze and interpret complex experimental data, present findings effectively, and contribute to scientific discussions and publications.
- Maintain accurate and detailed experimental records and contribute to the development of intellectual property.
- Stay current with scientific literature and new technologies in antibody engineering and drug discovery.
Benefits
- Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
- In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
