Scientist, ADC Chemistry

BioNTech•Cambridge, MA

8d•Onsite

About The Position

BioNTech is developing novel Antibody-Drug Conjugates (ADCs) and other targeted therapeutics for the targeted treatment of cancer with the goal of maximizing efficacy and minimizing toxic effects to patients. To achieve this goal ADCs and/or degraders will be prepared, evaluated in a battery of in vitro and in vivo assays, then based on results, improved therapeutics will be developed. As a Chemistry Scientist in Global ADC Innovation Unit, you will help design and synthesize the payloads, linkers, and linker-payloads required to generate next generation ADCs. You may also be involved in the conjugation step, attaching linker-payloads to various antibodies. You will work closely with team members who have diverse backgrounds in Biology, Pharmacology and other disciplines. You will also prepare presentations for the team, and possibly for upper management, including progress updates and proposals for linker-payload improvements.

Requirements

Ph.D. in synthetic organic chemistry, with 3+ years of industry experience developing ADC payloads, ADC linkers, and ADCs.
Hands-on experience preparing complex organic molecules and using HPLC, LC-MS and NMR for purification/analysis
Proven track record of creative thinking and consistent delivery as demonstrated by publications and presentations
Excellent interpersonal, networking, and communication skills
Must be able to work on site in our synthetic laboratory

Nice To Haves

Experience with analytical methods used in ADC payload, ADC linker and ADC development
Experience in molecular modeling
Experience in degrader chemistry

Responsibilities

Work with a team designing and producing novel ADC payloads, ADC linkers, ADCs and other targeted therapeutics
Design, synthesize, and purify small molecules, linkers, potent payloads, and potentially conjugate them to proteins.
Work in a safe manner, using appropriate containment for potent compounds.
Use NMR and HPLC/UPLC techniques to prove the identity and purity of prepared compounds
Prepare presentations and work cross-functionally within the organization in various areas including formulation, drug delivery, pharmacokinetics, and pharmacodynamics
Liaise with BioNTech partners, CROs and CDMOs

Benefits

Medical, Dental and Vision Insurance
Life, AD&D, Critical Illness Insurance
Pre-tax HSA & FSA, DCRA Spending Accounts
Employee Assistance & Concierge Program (EAP) available 24/7
Parental and Childbirth Leave & Family Planning Assistance
Sitterstream: Virtual Tutoring & Childcare Membership
Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating) & Year-End U.S. Shutdown.
401(K) Plan with Company Match
Tuition Reimbursement & Student Loan Assistance Programs
Wellbeing Incentive Platforms & Incentives
Professional Development Programs
Commuting Allowance and subsidized parking
Discounted Home, Auto & Pet Insurance