SAP S/4HANA Manufacturing Systems Specialist

Immatics•Houston, TX

1d•Onsite

About The Position

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME , a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics . We are seeking an SAP S/4HANA Manufacturing Systems Specialist to support our US Computer Systems Validation team. The SAP S/4HANA Manufacturing Systems Specialist i s responsible for configuring, supporting, and o ptimizing SAP S/4HANA manufacturing solutions in a regulated ( G xP ) environment. This role partners closely with manufacturing business users, SAP developers, engineering, and validation teams to deliver compliant, efficient, and scalable manufacturing processes. The position requires a strong combination of SAP manufacturing configuration e xpertise , Engineering Change Management (ECM) experience, technical collaboration skills, and experience working within validated SAP landscapes.

Requirements

Bachelor’s degree in IT, Engineering, Manufacturing, or a related field, or equivalent experience.
Minimum of 5 years of hands-on experience working in SAP S/4HANA environments
Hands-on experience configuring SAP S/4HANA manufacturing solutions.
Experience supporting Engineering Change Management (ECM) processes and Master data Updates within SAP.
Experience working with SAP developers on technical solutions and system integrations.
Experience supporting SAP systems in regulated ( GxP ) environments with validation requirements.
Strong understanding of end-to-end manufacturing and engineering processes.
Strong SAP S/4HANA manufacturing functional and technical expertise
Solid understanding of Engineering Change Management (ECM) and change control processes
Effective cross-functional communication and collaboration
Strong analytical and problem-solving skills
High attention to detail and documentation discipline
Ability to operate effectively in a validated, audit-ready environment

Nice To Haves

Experience in pharmaceutical, biotech, medical device, or other regulated manufacturing industries.
Experience with SAP ECC to S/4HANA manufacturing migrations.
Knowledge of shop floor integration, MES, or manufacturing execution systems.

Responsibilities

Configure and support SAP S/4HANA manufacturing processes, primarily with integration to Extended Warehouse Management (EWM), Materials Management (MM ) and Quality Management (QM).
Maintain and support manufacturing master data including BOMs, routings, work centers, production versions, and production orders.
Support Engineering Change Management (ECM) processes, including configuration and management of engineering changes impacting BOMs, routings, and production data.
Ensure engineering changes are properly assessed , documented, approved, and implemented in SAP in alignment with change control and validation requirements.
Translate manufacturing and engineering business requirements into clear functional and technical specifications.
Collaborate with SAP developers on custom developments, enhancements, interfaces, and integrations related to manufacturing and ECM processes.
Support SAP Computer System Validation (CSV) activities, including impact assessments, testing, and documentation in compliance with GxP requirements.
Partner with validation and quality teams to ensure all system and engineering changes meet regulatory and audit standards.
Provide production support, issue resolution, and root cause analysis for manufacturing- and engineering-related SAP issues.
Support system upgrades, enhancements, and continuous improvement initiatives within SAP S/4HANA manufacturing.

Benefits

Competitive rates for Health, Dental, and Vision Insurance
4 weeks of P aid Time off, granted up front each year and prorated for first and last year of employment.
Sick Time Off – 56 hours
12 Paid Holidays
100% Employer-Paid Life Insurance up to at 1x annual salary
100% Employer Paid Short- and Long-Term Disability Coverage
401(k) with Immediate Eligibility & company mat ch… You are eligible for 401(k) plan participation as of your first paycheck. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employmen t , 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
P artially paid Parental Leave for eligible employees. (3 weeks)
Additional voluntary employee paid coverages including Accident , Hospital Indemnity, and Critical Illness
Employee Paid Identity Theft Protection and Pet Insurance
Opportunities to work with leading experts in the field of T-cell immunotherapy.
Company provided learning and development opportunities
Fast paced, high demand collaborative and dynamic environment.