Research Technician II- Cheng Lab

Cleveland Clinic

1d•Onsite

About The Position

Join Cleveland Clinic’s Main Campus as a Research Technologist in the Cleveland Clinic Genome Center, directed by Dr. Feixiong Cheng. This role involves participating in the design, organization, and execution of daily research activities to support experimental research in functional genomics, stem cell-based disease modeling, and molecular biology. The position requires sustained, hands-on work in cell culture, sample preparation, sequencing workflows, and general laboratory operations. Candidates will gain exposure to cutting-edge functional genomics and disease modeling, contribute to long-term funded projects, and play a meaningful role in discoveries that translate to human health, aligning with Cleveland Clinic’s mission to advance patient care through high-impact biomedical research. The role operates on a day shift from 8:30 a.m. – 5:00 p.m. with flexible start/end times, and occasional weekend shifts are required.

Requirements

High School Diploma or GED and four years of experience in a research or related laboratory environment OR Associate's degree in laboratory science and three years of experience OR Bachelor’s degree and two years of experience OR Master’s degree and one year of experience
Ability to perform work in a stationary position for extended periods
Ability to operate a computer and other office equipment
Ability to communicate and exchange accurate information
Ability to distinguish color
Manual dexterity to handle specimens and repair equipment
Ability to lift and transport equipment or specimens weighing up to 20 pounds
Follows standard precautions using personal protective equipment as required.

Nice To Haves

Bachelor’s or Master’s degree
Hands-on experience in cell culture, molecular biology techniques, sample preparation, and laboratory organization
Comfortable executing routine and semi-technical experiments independently
Strong time management, documentation skills
Ability to work in a fast-paced research environment

Responsibilities

Participate in daily research project activities.
Plan, organize, perform and monitor daily project protocols.
Collect, prepare and maintain required research documentation, including informed consent records, case records, clinical notes and medical reports.
Report and assist with managing protocol deviations, adverse events and other project-related issues.
Be responsible for the general maintenance and upkeep of the lab.
Order and purchase supplies, gather information on new equipment and recommend purchases.
Assist with cell culture, including maintenance of iPSC-derived neurons, microglia, astrocytes, and/or brain organoids.
Support experiments in functional genomics such as CRISPR/Cas9 or CRISPRi/a workflows, Basic molecular biology (PCR, cloning, DNA/RNA extraction) and Next-generation sequencing (NGS) library preparation.
Perform sample processing, reagent preparation, buffer making, and general laboratory organization.
Assist with FACS sample preparation, immunostaining, and microscopy as needed.
Maintain detailed and accurate experimental records in lab notebooks and electronic databases.
Follow standard operating procedures, safety guidelines, and quality control measures.