UNIV - Research Specialist II - Department of Pharmacology and Immunology

Medical University of South Carolina • Charleston, SC

11d

About The Position

A Research Specialist II is needed for proteomic biomarker studies. Studies will require proteomic sample preparation, HPLC, tandem mass spectrometry, database searching, proteomic analysis at the protein and peptide level and integration with mass spectrometry imaging experiments.

Requirements

• A bachelor's degree in chemistry, biology, or other natural, life or health care science and one year work experience directly related to the assigned research area.
• Ability to perform job functions in an upright position.
• Ability to perform job functions in a seated position.
• Ability to perform job functions while walking/mobile.
• Ability to climb, using step stool.
• Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries.
• Ability to work in confined/cramped spaces.
• Ability to bend at the waist.
• Ability to twist at the waist.
• Ability to fully use both hands/arms.
• Ability to perform repetitive motions with hands/wrists/elbows and shoulders.
• Ability to fully use both legs.
• Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions.
• Ability to maintain good olfactory sensory function/distinction.
• Ability to lift materials up to 20 lbs., unassisted.
• Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted.
• Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted.
• Ability to lift file boxes, from floor level to counter tops, unassisted.
• Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted.
• Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted.
• Ability to push/pull file boxes from one location to another at floor level.
• Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted.
• Ability to perform gross motor functions with frequent fine motor movements.
• Ability to maintain 20/40 vision, corrected, in one eye or with both eyes.
• Ability to match or discriminate between colors, normally.
• Ability to hear and recognize various alarms emitting from work area systems.
• Ability to hear and/or understand conversations.
• Ability to work in a darkroom for processing film, etc.
• Ability to be qualified physically for respirator use, initially and annually.
• Ability to work rotating shifts as required.
• Ability to work overtime as required.
• Ability to learn and use new processes, tools and equipment as required.

Nice To Haves

• Experience in one or more of the following desired: proteomics, chromatography, mass spectrometry, tandem mass spectrometry, trapped ion mobility, orbitrap, isotopic labeling, DIA, DDA, post-translational modifications
• The ideal candidate will have a college degree in chemistry, biology or one of the biological sciences

Responsibilities

• Sample organization and preparation. Individual will be familiar with randomization approaches to pre-prep sample organization using clinical characteristics and sample preparation for mass spectrometry studies. Sample preparation will include automated enzymatic digestion, buffer preparation, application of antibody tags in a clean environment. Individual will be capable of reaching milestone achievements.
• Data analysis. Individual will collaborate with multiple labs for image data processing and data modeling by simulators. Individual be familiar with verification and validation procedures to ensure appropriate modeling.
• Individual will use a variety of programs such as Excel, GraphPad, ImageJ and SPSS, python and R to report data. Individual will also learn and be able to communicate new proteomic software for peptide clustering and proteomic reporting.
• High throughput assays.
• Training students or visiting scholars in laboratory workflows surrounding proteomics
• Maintain laboratory equipment. Individual will include system suitability tests on equipment used in each part of the study and record findings, troubleshooting when necessary.
• Keeping the lab safe, clean and compliant by following PPE and MUSC guidelines for safety in the laboratory.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 5,001-10,000 employees