Research Scientist, Level 1 (Center for Dementia Research) (210-2025-62)
About The Position
The position provides a rich multidisciplinary environment for postdoctoral training and more advanced career development. The candidate will receive a multidisciplinary training investment in performing multi-'omics expression profiling studies at the single population and subregional level relevant towards understanding the potential pathogenesis of selective neuronal vulnerability during the progression of dementia. The position available involves studies of cellular and animal models and postmortem human brain tissues to investigate vulnerable neuronal populations via single population RNA sequencing (RNA-seq), digital spatial profiling (DSP), and related validation strategies within the hippocampus, basal forebrain, and cortex.
Requirements
- Bachelor's degree and two years of professional research experience in an appropriate field or master's degree in an appropriate field may substitute for one year of the experience.
Nice To Haves
- Ph.D. in Neuroscience/Molecular Cellular Neuroscience
- Experience with human neuroanatomy
- Experience with molecular and cellular neuroscience in mouse and/or postmortem human brain tissues
- Experience with laser capture microdissection
- Experience with RNA-sequencing
- Experience with digital spatial profiling
- Training in statistics/bioinformatics
- Previous work with mice
- Additional technical experience with RNA amplification, siRNA knockdown delivery, surgical manipulations, ELISA, confocal microscopy, Western blotting, and real-time qPCR is strongly recommended.
Responsibilities
- Job requirements include microaspiration of pyramidal neurons and basal forebrain cholinergic neurons from mouse brain and postmortem human brain tissues via laser capture microdissection (LCM)
- Preparing samples for RNA-seq
- Cryocutting frozen postmortem human and animal model brains for digital spatial profiling (DSP)
- Subsequent bioinformatic and pathway analyses of the resultant datasets.
Benefits
- Excellent Benefits Package
- Affirmative Action/Equal Opportunity Employer - Disabled/Veteran, 41 CFR 60-741.5(a) and 41 CFR 60-300.5(a) compliant.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Number of Employees
101-250 employees
