Research Scientist I, Biology
About The Position
C4 Therapeutics (C4T) is a clinical-stage biopharmaceutical company focused on targeted protein degradation science to create new medicines. The company is seeking a highly motivated and detail-oriented Research Scientist I to join its Discovery Biology team. This role involves contributing to the discovery and development of novel targeted protein degraders for autoimmune, inflammatory, and neuroinflammatory diseases. The scientist will be responsible for designing and executing in vitro and ex vivo studies to investigate immune mechanisms, validate therapeutic targets, and characterize the biological impact of new therapeutic candidates. This is a hands-on, lab-based position offering significant scientific ownership and requiring close collaboration with cross-functional teams, directly shaping the next generation of immunotherapy.
Requirements
- A PhD in Immunology with a minimum of two years of post-graduate experience, or an M.S degree with at least eight years of post-graduate experience, including direct experience with autoimmune or immunological diseases in non-oncology indications (e.g. Lupus, Rheumatoid Arthritis, IBD, etc.), primary human immune cell isolation, culture, and functional assays and a strong background in immune cell biology relevant to autoimmune and/or inflammatory diseases.
- Experience working with autoimmune or inflammatory disease models or autoimmune patient-derived samples.
- Experience with in vitro cell stimulation assays and functional readouts, as well as proficiency in multicolor flow cytometry and other immunological techniques such as ELISA, MSD, qPCR, and western blotting.
- Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills.
- Proficiency in software such as PowerPoint, Word, GraphPad, FlowJo, etc., for data analysis, figure generation, and presentation.
Nice To Haves
- Experience in a biotech or pharmaceutical setting.
- Familiarity with targeted protein degradation, or small‑molecule drug discovery.
Responsibilities
- Design, execute, and analyze in vitro and ex vivo assays using primary human cells relevant to autoimmune disease biology (e.g., PBMCs, monocytes, B cells, T cells, fibroblasts, neurons, etc.).
- Perform flow cytometry, ELISA, cytokine profiling, and other immunoassays to assess compound activity and support mechanism of action and target validation studies.
- Develop and optimize cell‑based assays using primary human immune cells and/or patient‑derived samples.
- Isolate and culture primary human cells from blood samples or other suitable sources.
- Integrate human biology, genetics, and translational biomarkers into experimental strategies.
- Assist in identifying disease‑relevant readouts and pharmacodynamic biomarkers.
- Stay current with autoimmune disease biology and therapeutic modalities, proposing new assays, models, or hypotheses.
- Collaborate closely with cross-functional teams including lead discovery, chemistry, and translational science to support program goals.
- Maintain accurate and detailed experimental records in electronic lab notebooks.
- Communicates data and findings in a clear/concise manner in team meetings and contributes to scientific discussions.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
11-50 employees
