Research Lab Tech I, Hematology Hollenhorst Lab

Mass General Brigham • Boston, MA

22h • Hybrid

About The Position

The Hollenhorst Lab at Mass General Brigham applies innovative biochemical strategies to study clinically relevant questions regarding proteins that regulate bleeding and clotting. The primary goal is to advance the understanding of hemostasis and thrombosis basic biology, focusing on questions directly relevant to patient care. The lab is seeking an enthusiastic and motivated individual to conduct experiments under the guidance of the principal investigator or a senior lab member. The role involves performing techniques such as western blots, immunoprecipitation, protein purification, and preparing samples for mass spectrometry analysis. The successful candidate will operate with a high degree of independence, maintain detailed notebooks, manage data, and execute other laboratory experiments pertinent to understanding platelets and coagulation factors. Ideal candidates should possess training in wet lab techniques, strong organizational skills, and a drive for continuous learning and skill development. This position is particularly well-suited for individuals aiming for a 1-2 year research experience before pursuing PhD and/or MD programs, with direct mentorship and career advice provided by the principal investigator, including clinical shadowing opportunities for those interested in medical school. The Hollenhorst laboratory is situated in the Harvard Institutes of Medicine building within the Longwood Medical Area, affiliated with Brigham and Women’s Hospital Division of Hematology and Harvard Medical School. It collaborates with institutions like the National Center for Functional Glycomics and the Broad Institute, offering access to state-of-the-art core facilities and a supportive, well-equipped research environment.

Requirements

• Bachelor's degree.
• A positive attitude and eagerness to learn.
• Comfortable with working independently and in a team.
• Good oral and written communication skills.
• Ability to learn and perform a variety of laboratory protocols, to identify potential problems and troubleshoot solutions.
• Strong organizational skills.
• Ability to logically present data.
• Sound judgment regarding time-management and laboratory safety.

Nice To Haves

• Bachelor's degree in biology, chemistry, or a related scientific field.
• Previous experience (6 months+) with techniques in experimental biology, chemistry and/or biochemistry.
• Prior training in western blot, immunoprecipitation, protein purification by liquid chromatography, flow cytometry, and preparation of samples for mass spectrometry analysis.

Responsibilities

• Perform routine and non-routine experiments, which are moderate to complex, with increasing independence. These include western blot, immunoprecipitation, protein purification by liquid chromatography, flow cytometry, and preparation of samples for mass spectrometry analysis.
• Process platelets and plasma samples from donors and patients.
• Maintain long-term tissue cultures of human cell lines, monitor cells for viability and contamination.
• Maintain a detailed electronic laboratory notebook to reproduce experiments precisely.
• Consult with the principal investigator and implement adjustments in experimental design.
• Prepare laboratory reagents and chemicals, organize storage. Meticulously maintain and update databases of laboratory supplies and storage. Order new supplies on time to maintain inventory.
• Perform routine maintenance and calibration of laboratory equipment, if necessary.
• Become proficient in Excel, FlowJo, and GraphPad Prism as needed analyze and critically evaluate data.
• Present data and relevant research publications in lab meetings. Help to prepare presentations and written articles for publication.
• All other duties, as assigned.

Benefits

• Competitive base pay
• Comprehensive benefits
• Career advancement opportunities
• Differentials
• Premiums
• Bonuses
• Recognition programs designed to celebrate your contributions and support your professional growth

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 5,001-10,000 employees