Regional Business Director, Rare Disease - West

Alnylam Pharmaceuticals

1d • $204,000 - $276,000 • Remote

About The Position

We are seeking an experienced Regional Business Director (RBD) to support the promotion of OXLUMO® (lumasiran) for Primary Hyperoxaluria Type 1 and GIVLAARI® (givosiran) for Acute Hepatic Porphyria. This is an exceptional opportunity to build a meaningful legacy of support for patients, caregivers, and the PH1 and AHP communities.
The RBD will lead and develop a high-performing team of Business Account Executives (BAEs), driving disease awareness and product education among healthcare professionals. In addition to coaching and performance management, the RBD will provide market insights to inform commercial strategy, champion a customer-oriented culture, and foster a team environment grounded in accountability and excellence.
The RBD will embody Alnylam's core values: commitment to people, purposeful urgency, passion for excellence, innovation and discovery, open culture, and an unwavering commitment to integrity.
The position reports to the Head of Rare Sales.

Requirements

• Bachelor’s degree required; science focus is strongly preferred. MBA or PhD is a plus.
• 5+ years of experience leading commercial teams; 7+ years in sales, marketing, commercial operations, or account management within biotech, medical device, or specialty pharma.
• Rare/orphan disease experience preferred.
• Proven experience training and managing BAEs across multiple specialties and working cross-functionally across sales, marketing, market access, and patient services.
• In-depth reimbursement knowledge of Buy/Bill and Part B & D, including experience with in-house patient support services and site-of-care development.
• Strong familiarity with hospital/institutional environments and the P&T committee process.
• Demonstrated ability to lead and influence a matrixed organization across multiple teams and functions.
• Strong planning, prioritization, and organizational skills with the ability to manage competing priorities effectively.
• Working knowledge of relevant legal and regulatory requirements within the biotech/pharmaceutical industry.
• Demonstrated commitment to ethics and integrity in all aspects of work.
• Valid driver's license required; regional travel approximately 60–70%.

Responsibilities

• Lead, coach, and develop a high-performing BAE team focused on disease awareness and product education across PH1 and AHP patient communities.
• Apply strong sales management, strategic planning, financial acumen, and analytical capabilities to align field execution with broader commercial strategy.
• Proactively analyze market dynamics and develop forward-looking action plans; clearly communicate market context and proposed direction to both leadership and the field team.
• Coach team members to meet and exceed performance targets, with an emphasis on compliance, business planning, and cross-functional alignment.
• Leverage deep market knowledge to provide insights that shape and refine commercial strategy.
• Build best-in class team culture by attracting, developing, and retaining top sales talent.
• Cultivate a customer-oriented culture that prioritizes patient needs, value-added services, and seamless execution.
• Allocate and manage regional resources to support strategic and operational excellence.
• Align people, processes, and communication systems effectively across a complex, matrixed organization.
• Inspire and motivate the team by clearly articulating strategy, vision, and future objectives.

Benefits

• We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match.
• Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks.
• We also offer generous family resources and leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Number of Employees: 501-1,000 employees