Professional Research Assistant

University of Colorado • Denver, CO

4d

About The Position

The research program focuses on developing advanced optical nanoprobes to improve cancer detection and image-guided surgery for pancreatic ductal adenocarcinoma (PDAC). Our laboratory develops biocompatible, near-infrared (NIR) chemiluminescent chitosan-based nanoparticles (CNPs). By combining synthetic chemistry with in vivo optical imaging and orthotopic mouse models, we aim to accurately locate deep cancerous tissues and metastatic lymph nodes, ultimately enhancing intraoperative techniques and patient outcomes.
This collaborative position directly supports our research on dual-mode chemiluminescence and fluorescence (CL/FL) imaging for guided surgery. The researcher will work extensively with orthotopic PDAC mouse models, performing cancer cell inoculation, intravenous injections, and real-time whole-body imaging using IVIS. Core duties also include conducting biodistribution and toxicity studies, ex vivo tissue imaging, and microscopic analysis using confocal laser scanning microscopy. The candidate will actively assist in data analysis to quantify nanoparticle targeting efficacy.

Requirements

• Bachelors of Science degree in Chemistry, from an accredited university.
• Five (5) or more years of experience in organic chemistry and nanomaterial fabrication.

Nice To Haves

• One (1) or more years of experience in vitro cell works
• Familiarity with preclinical models and the theoretical nuances of tumor biology.
• Understanding the bridge between laboratory research and clinical oncology.
• Proficiency in optimizing high-level equipment (IVIS, CLSM) and executing precise protocols like ex vivo processing.
• Ability to troubleshoot experimental variables and quantitatively analyze complex imaging data.
• Ability to work seamlessly across interdisciplinary teams, including PIs and surgical staff.
• Intrinsic commitment to advancing PDAC research and improving patient outcomes.

Responsibilities

• Optical Imaging: Conduct whole-body and ex vivo chemiluminescence (CL) and fluorescence (FL) imaging to track nanoparticle biodistribution.(40%25)
• Data Analysis: Quantify and analyze imaging data using specialized software, such as Living Image and ImageJ.(40%25)
• Collaborative Research: Contribute to data interpretation and the preparation of scientific publications and technical reports. (20%25)

Benefits

• The University of Colorado Denver provides generous leave, health plans and retirement contributions that add to your bottom line.
• Benefits: https://www.cu.edu/employee-services/benefits

What This Job Offers

• Job Type: Part-time
• Career Level: Entry Level