Principal Scientist In Vivo Immunology

GSK • Cambridge, MA

2d

About The Position

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D Job Purpose: The Principal Scientist in the in vivo immunology team will serve as the preclinical in vivo study lead and will represent the project team in spearheading GSK’s innovation of novel viral vaccines and platform programs. You will have the opportunity to lead the in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners in a collaborative and matrix team. You will design and write in vivo study protocols, coordinate and initiate preclinical studies, conduct and analyze experimental results pertaining to the understanding of the immune responses from novel vaccine candidates, formulations, and platforms. Key responsibilities: This role will provide you with the opportunity to lead key activities and to progress your career based on performance.

Requirements

• Doctor of Philosophy (Ph.D.) or Master of Science (M.S.) degree in immunology or a related field.
• 4+ years of working experience post Ph. D or 6+ years of working experience post M.S in immunology or in these related field.
• Experience in conducting in vivo animal studies within the fields of vaccines, infectious diseases, or immunology.
• Experience in small rodent handling and drug administration, in-study blood sampling, necropsy, tissue harvest, and processing.
• Experience in designing, executing, and analyzing immune response readouts using conventional or spectral flow cytometry.

Nice To Haves

• Matrix management experience.
• A collaborative team player with strong interpersonal skills to work with diverse groups within the organization.
• Detail-oriented with the agility to balance multiple projects.
• Extremely organized with experience in documentation of study protocols and reports.
• Experience with immune-response related readout methods such as ELISPOT, Luminex, and qPCR methodologies.
• Experience preparing and delivering written and verbal communications in a professional setting.

Responsibilities

• Design, plan, conduct, coordinate, monitor, and analyze in vivo murine studies for vaccine and platform programs. May serve as the preclinical in vivo lead.
• Implement and ensure adherence to GSK and regulatory requirements for compliance with Institutional Animal Care and Use Committee (IACUC) guidelines through writing and reviewing in vivo study protocols and participating in the independent scientific review committee.
• Conduct dosing, In Vivo Imaging System (IVIS) imaging, necropsy, and tissue harvest from animal studies and supervise technicians conducting these activities
• Perform experiments characterizing cell-mediated immune response for preclinical immunogenicity or challenge studies using flow cytometry, Enzyme‑Linked ImmunoSpot (ELISPOT), Luminex or Meso Scale Discovery (MSD) assays and others.
• As a preclinical in vivo study lead, you will work in a matrix team to support the identification of novel vaccine candidates and support platform development.
• Prepare and document study protocols and final reports for projects as an author.
• Contribute to patent filing, Investigational New Drug (IND) submissions, and scientific publications.
• Present study plans and results at project meetings.
• Develop new experimental techniques based on project needs.
• Mentor and train junior scientists.

Benefits

• Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
• annual bonus
• eligibility to participate in our share based long term incentive program

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees