Principal Scientist, Computational Biology

Eikon Therapeutics, Inc.•Millbrae, CA

62d

About The Position

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon's discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets. Position We seek a Principal Scientist in Computational Biology to drive diverse early drug discovery efforts across Eikon's target portfolio. In this key role, the successful applicant will use their rigorous analytical skills in close collaboration with diverse discovery scientists to conceive and evaluate complex, progress-enabling experiments across our target portfolio. A natural collaborator, this individual will draw on their substantial experience performing analysis of traditional genomic, chemical biology, and high throughput experiments to elevate the work of others while identifying new targets and defining new drug discovery applications that are enabled by Eikon's unique technical capabilities. About You For this role we seek an experienced, rigorous, and results-driven computational scientist with a strong track record making high impact contributions proposing and advancing early research drug discovery programs. This person will be an enthusiastic and generous collaborator who is comfortable working in a fast-paced, cross-functional environment uniting diverse disciplines and subject matter experts skilled in traditional and emergent drug discovery technologies. This person will be a curious, detail-oriented, and strategic thinker who can draw on deep technical and biological knowledge to synthesize data from diverse internal and external sources to resolve nuanced scientific questions. They are comfortable driving the design, analysis, and evaluation of high throughput and genomics experiments to discover novel biological insights that they effectively convey to both technical and non-technical audiences. This combination of expansive knowledge, good judgment, and passion for drug discovery makes you an inspiration to others who can lead by example through both formal reporting and informal mentorship.

Requirements

PhD or equivalent in a computationally-aligned field plus 10 years' relevant industry experience; minimum with 5 years' experience in drug discovery
Excellent interpersonal, written, and verbal communication skills, with significant experience collaborating closely with experimental teams and providing mentorship to junior scientists
Strong practical expertise in the design, evaluation, and integration of high throughput experiments, as well as deep understanding of the relevant associated statistical techniques
Expertise using one or more high level programming language (e.g. R, Python, or similar) to solve biological problems; well versed in modern coding and computing best practices such as cloud deployment, version control, containerization, etc.
Substantial problem-solving skills and creativity as applied to drug discovery questions; experience performing in-depth analysis of experiments, biobanks and patient consortium data to validate known biology and nominate new targets

Nice To Haves

Additional weight will be given to qualified applicants with significant expertise in oncology, neuroscience, methodological development, biomarker discovery, and/or advanced imaging applications

Responsibilities

Use computational approaches to drive drug discovery programs forward in close collaboration with experimentalists throughout Eikon's target portfolio
Apply statistical, biological, and experimental expertise to evaluate complex experiments and distill information from diverse sources to reach relevant and testable biological conclusions
Identify innovative analytical approaches to answering key biological questions, perform analyses to define their appropriate use, and apply these approaches to further therapeutic programs
Collaborate with informaticists and engineers to prototype new analytical approaches and broadly enable computational capabilities
Mentor junior scientists across functions by providing an example of principled, data-driven problem solving that is supported by deep engagement with underlying biological questions
Contribute to the preparation of scientific publications, presentations, and grant proposals, showcasing the impact of bioinformatics analyses on advancing scientific knowledge

Benefits

401k plan with company matching
Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
Mental health and wellness benefits
Weeklong summer and winter holiday shutdowns
Generous paid time off and holiday policies
Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
Enhanced parental leave benefit
Daily subsidized lunch program when on-site

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