Principal Scientist, Chemical Process and Analytical Development

Pfizer • Bothell, WA

1d • Onsite

About The Position

The Chemical Process and Analytical Development (CPAD) group located in Bothell, WA is responsible for the development of chemical processes and analytical methods for novel drug-linkers (linker-payloads) used in antibody-drug conjugates (ADCs). Our process chemists, analytical chemists, and chemical engineers collaborate to discover phase-appropriate synthetic routes and chemical processes to accelerate the delivery of life saving medicines to patients, and to develop robust and innovative synthetic processes to novel commercial drug-linker candidates that drive the next generation of targeted cancer therapy. As a Principal Scientist in CPAD, you will provide technical leadership to a team of process chemists engaged in route screening/selection, process development, and process characterization for our growing drug-linker portfolio. You will drive the development of safe and scalable chemistry by leveraging state-of-the-art technologies such as high-throughput experimentation, data-rich experimentation, catalysis, continuous processing, and predictive technologies. You will spearhead the advancement of Pfizer’s oncology portfolio through personal laboratory effort as well as oversee external resources through technology transfer and campaign execution at CDMOs. You will serve as a technical and strategic leader for early and late-phase programs while mentoring junior staff members in a supportive and inclusive work environment. You will propose technical and strategic solutions to management and represent process chemistry in cross-functional teams requiring excellent communication skills. Finally, you will be expected to establish an external presence as technical leader in the field by authoring journal articles and presenting at leading external scientific meetings.

Requirements

• PhD in Organic Chemistry with 4+ years of experience in pharmaceutical process development, including route design, scale-up, and GMP manufacturing; or a master’s degree with 10+ years of relevant experience.
• Proven track record of scientific innovation and impact, demonstrated through authorship of peer-reviewed publications, patents, or presentations at recognized scientific conferences.
• A sound understanding of modern synthetic organic chemistry principles, process development, engineering, analytical and purification technologies.
• Excellent written and oral communication skills, with a demonstrated ability to effectively collaborate with stakeholders.
• In-depth knowledge of pharmaceutical development from pre-clinical to commercialization.
• Experience in a regulated pharmaceutical environment including GMP deliveries and regulatory authoring.
• This is an on-site designated role, and you will be expected to work five days a week.
• Research summary is requested to be submitted with your resume.

Nice To Haves

• Experience with drug-linkers for ADCs or other targeted mixed-modality therapeutics.
• Experience in mentoring scientific staff, both directly and in a matrix environment.
• Experience with technology transfer activities and CRO/CDMO resource management.
• Experience from innovator pharma company is preferred.

Responsibilities

• Design and execute well-planned laboratory experiments that require complex data analysis.
• Maintain high standards for all laboratory records, reports, patents, regulatory documents, and external communications.
• Employ state-of-the art technologies including high-throughput experimentation, data-rich experimentation, computational tools, and predictive software to accelerate process development.
• Be recognized as a technical leader internally and externally by authoring publications and presenting externally.
• Drive technical aspects of early and late phase pharmaceutical development.
• Persuasively communicate abstract concepts, ideas, and solutions to project teams, leadership, and cross-functional teams.
• Establish and deliver on tight timelines aligned with our portfolio goals.
• Promote a supportive and inclusive work environment and mentor junior staff.
• Maintain an understanding of the activities and research carried out by the project team members.
• Lead authoring for patents and regulatory documents.
• Leverage knowledge and experience to guide cross-functional team decisions.
• Build strong relationships with stakeholders to advocate for our department.

Benefits

• participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program
• a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• paid vacation, holiday and personal days
• paid caregiver/parental and medical leave
• health benefits to include medical, prescription drug, dental and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees