Principal Scientist, Biology

Atavistik Bio • Cambridge, MA

3d

About The Position

Atavistik Bio is a privately-held clinical stage biotechnology company accelerating the discovery and development of transformative precision allosteric therapeutics to address serious unmet patient needs. Our proprietary AMPS™ platform allows us to rapidly unlock functional cryptic pockets across a broad range of target classes to accelerate the development of groundbreaking medicines. We have rapidly established an emerging pipeline of allosteric therapeutics with the potential to achieve superior efficacy and tolerability profiles by leveraging the power of allostery.

Atavistik Bio is led by an experienced team of drug hunters with a proven track record of developing marketed small molecule therapies and supported by top-tier investors, including The Column Group, Nextech Invest, Lux Capital, and Regeneron Ventures.

We are seeking a strategic and dynamic Principal Scientist with deep expertise in hematologic malignancies in cell and in vivo models, to join our R&D group and work with an enthusiastic team of highly skilled scientists in a fast-paced environment. Reporting to the VP, Head of Biology, this individual will be responsible for leading the biology and translational research strategy for small molecule drug candidates. The ideal candidate will have extensive experience in studying the biology behind hematologic malignancies, drug development, biomarker identification, and the ability to work cross-functionally in a dynamic environment.

Requirements

• PhD. in Biology with 5+ years of experience in industry, with a strong focus on drug discovery in hematologic malignancies.
• Strong interpersonal skills and ability to build strong collaborative relationships in a cross-functional environment is a must.
• Deep knowledge of preclinical in vivo models of hematologic malignancies, in particular myeloproliferative neoplasms.
• Ability to think strategically with consideration of translational proof of concept, competitive landscape, and optimal patient populations.
• Strong oral and written communication skills, with experience presenting complex scientific data to both internal and external stakeholders, including regulatory agencies.

Responsibilities

• Work closely with broader drug discovery scientific team to progress compounds from screening to preclinical animal models.
• Work with CRO and academic partners on a wide-range of drug discovery efforts including cell-based screening and primary patient cell-based assays.
• Partner with CROs and academic partners to design and execute in vivo PK/PD and efficacy models.
• Develops and executes the translational science strategy in collaboration with the Clinical Development organization.
• Designs and implements translational research plans to identify and validate biomarkers for patient selection strategy, treatment response, and disease progression.
• Clearly communicates the biology, translational research strategy, data, and other information to employees, company leadership, and external stakeholders including key opinion leaders, board members, and investors.
• Supports the preparation of regulatory documents, including IND submissions, clinical study protocols, and reports.
• Drafts and submits data for scientific publications and presents our research and development programs at scientific conference and to regulatory agencies.

Benefits

• Atavistik Bio offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree