Principal Scientist, ADME/PK

Shasqi

7d • Remote

About The Position

We are seeking an experienced and hands-on Principal Scientist, ADME/PK to lead and contribute to pharmacokinetics, biodistribution, and translational modeling efforts for a next-generation tumor targeting technology based on a click chemistry enabled pre-targeting.
You will work at the interface of chemistry, biology, and translational sciences to design and interpret studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment.

Requirements

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field.
• 4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs.
• Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics).
• Strong experience designing and interpreting in vivo PK and biodistribution studies.
• Demonstrated experience with QSP and PK/PD modeling.
• Experience with modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar).

Nice To Haves

• Experience with pre-targeting approaches, multi-component therapeutics, or bioorthogonal chemistry systems.
• Familiarity with click chemistry reactions (e.g., tetrazine–TCO) in biological systems.
• Background in oncology, targeted therapeutics, or drug delivery platforms.
• Experience with imaging-based biodistribution (e.g., PET/SPECT, fluorescence).
• Knowledge of regulatory expectations for PK/ADME in IND filings.
• Strong publication record and presentation skills.

Responsibilities

• Define and execute ADME/PK strategies for pre-targeted therapeutics that consist of biologics and small molecules.
• Lead PK/PD and biodistribution strategy to support platform validation and pipeline programs.
• Partner cross-functionally with chemistry, protein engineering, bioanalytical, and pharmacology/toxicology teams to optimize delivery efficiency and exposure.
• Serve as the subject matter expert on PK for pre-targeting systems and click chemistry-enabled therapeutics.
• Design, analyze, and interpret PK, biodistribution, and mass balance studies across components of the technology to guide therapeutic design, validation, and development.
• Collaborate with bioanalytical assay development team to support assay development.
• Build and apply PK/PD and mechanistic models to predict human dosing and scheduling.
• Translate preclinical data into clinical hypotheses and first-in-human strategies.
• Work closely with CMC and analytical teams to ensure bioanalytical readiness.
• Partner with toxicology and regulatory teams to support IND-enabling studies.
• Present data and strategy to leadership, investors, and external collaborators.

Benefits

• Competitive base salary as part of a broader total rewards package.
• Equity: Included as port of total compensations.
• Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability.
• Flexible PTO and a WFH stipend to support remote work.
• Ongoing growth opportunities, professional development, and mentorship.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree