PK/PD Principal Scientist

Zoetis

4d•$114,000 - $185,000

About The Position

Zoetis, a global leader in animal health, seeks an enthusiastic colleague to join our Veterinary Medicine Research and Development (VMRD) PK/PD Scientist Team to discover and develop novel therapeutics for veterinary medicine. The successful candidate will be primarily responsible for designing, conducting, analyzing, and interpreting in vivo PK/PD studies in multiple species in support of projects from early research through late-stage development. This position will require a highly motivated and independent leader who can effectively collaborate with other team members to advance projects.

Requirements

Ph.D in pharmacology, biochemistry, or related field with 4 or more years of relevant pharmaceutical development experience.
Proven ability to design, analyze and interpret in vivo PK and PK/PD studies.
Skilled in the use of PK and PK/PD analysis software such as WinNonlin, Monolix or Watson.
Must have excellent verbal & written communication skills.
Self-starter, able to prioritize work and work efficiently with minimal supervision.
Working knowledge of bioanalytical methodology.

Nice To Haves

DVM DACVCP or DVM Dipl. ECVPT is highly desirable.
Experience with biotherapeutics (protein therapeutics) is highly desirable.
Knowledge of ADA assays and assessment of immunogenicity of biotherapeutics is highly desirable.
Experience in PK/PD modeling and simulation such as PBPK, QSP or population PK modeling using NONMEM, R, or related software is highly desirable.
Experience interacting with regulatory agencies is highly desirable.
Experience conducting GLP studies is desirable.

Responsibilities

Independently design and analyze in vivo PK/PD, PK and TK studies in multiple veterinary species, including writing study protocols and reports.
Provide PK and PK/PD modeling and simulation to help select lead candidates and optimize dose regimens.
Collaborate with bioanalytical team to assess suitability of analytical assays and forecast analytical requirements for projects.
Lead development of scientific strategy across therapeutic areas with a focus on mechanistic platforms/biomarkers to aid in translation, measurement of target engagement, and dose regimen predictions.
Work collaboratively and communicate effectively with multidisciplinary teams to design and prosecute studies in line with the strategic direction of the project.
Present research results to scientific teams, management, and regulatory agencies.
Write sections of regulatory submissions, respond to inquiries from regulatory agencies, and maintain knowledge of regulatory guidance documents.