Principal Research Scientist I, siRNA Therapeutics

AbbVie • South San Francisco, CA

8h

About The Position

We are seeking a highly motivated and collaborative scientist with a background in therapeutic siRNA to join the growing siRNA team at AbbVie. The candidate will be part of the newly formed siRNA team with a focus on progressing therapeutic siRNA pipeline progress for oncology indications. The successful candidate will be part of a growing therapeutic siRNA group working with cross-disciplinary teams internally and externally. The candidate will direct research and serve as a lead scientist on their own project and team and contribute scientific insights into multiple other projects.

Requirements

• BS, MS, or PhD with typically 14+ years (BS), 12+ years (MS), or 6+ years (PhD) of related work experience in biotech or pharma
• Previous experience with therapeutic siRNA, siRNA antibody conjugates, and downstream assays to measure efficacy is required
• Previous experience managing and leading direct report scientists
• Deep experience in cell culture techniques and downstream assays to evaluate RNAi compounds
• Previous experience in animal study design and downstream assays to evaluate genetic medicines
• Excellent communication and interpersonal skills.
• Listens and understands others’ point of view and articulates own perspective tacitly in order to clearly communicate scientific findings with key stakeholders

Nice To Haves

• Experience with extrahepatic delivery of therapeutic siRNA is a plus
• Candidate will be well versed in the field of oncology with previous experience preferred

Responsibilities

• Function as a principal investigator to advance internal siRNA technology and programs related to oncology indications
• Independent responsibility for project science within his/her area of expertise on one or more project teams
• Collaborate with therapeutic area colleagues to advance siRNA technology applied to internal programs.
• Direct research and mentor a group of scientists within area of expertise
• Optimize internal siRNA platforms for targeted functional delivery of siRNA
• Manage external CROs and internal resources to meet budget and timeline constraints
• Collaborate closely with internal colleagues to advance cross-functional collaborative experiments and projects
• Serve as a subject matter expert for siRNA delivery to target tissues and experimental design & execution
• Generate new scientific proposals and lead those efforts.
• Anticipate and critically evaluate scientific advanced or competitive threats and respond with appropriate new strategies.
• Clearly communicate technology achievements and needs with management and cross functional collaborators

Benefits

• paid time off (vacation, holidays, sick)
• medical/dental/vision insurance
• 401(k)
• short-term incentive programs
• long-term incentive program

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree