Research Scientist I

The Broad Institute•Cambridge, MA

22h•$88,000 - $124,000

About The Position

Embedded within the Broad Institute of Harvard and MIT, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate the deep biological insights emerging from the Broad community into new therapeutics. To accomplish this mission, we partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry professionals in pharmaceutical, biotechnology and venture capital firms and advance cutting-edge drug discovery projects. We create new technologies and work to apply the unique capabilities of the Broad Institute to enable new therapeutic approaches that will broadly benefit the scientific community. We are seeking a highly motivated and capable Research Scientist I to join the Biochemistry & Biophysics group. As a lab-based position, the candidate will be responsible for the development, implementation and execution of biophysical assays utilizing state-of-the-art capabilities to advance drug discovery projects, and experience in this area is required. The successful candidate will be a results-focused, team-oriented, creative bench scientist. They must be self-motivated and detail-oriented, exhibiting strong problem-solving skills and the ability to excel in a fast-track environment. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with cross-functional project teams in identifying and achieving research goals.

Requirements

Ph.D. in Biochemistry, Biophysics, Structural biology or related life science field with 0-2+ years of relevant lab experience
Biophysical assay development experience, with an advanced understanding of protein biochemistry and biophysics
Significant experience with bioanalytical instrumentation and techniques, including SPR (Cytiva, Carterra), BLI, ITC, MST, and/or NMR
Experience in recombinant protein expression and purification is desirable
Ability to function productively with complete independence and maintain detailed lab records of experiments using a digital notebook (ELN)

Nice To Haves

Experience in biophysical characterization of biologics (e.g., antibodies, nanobodies, bispecifics) is beneficial, but not required.

Responsibilities

Lead the development and execution of biophysical assays to support hit identification, validation, and lead optimization (e.g., SPR, BLI)
Characterize recombinant proteins and their interactions using biochemical and biophysical assays (e.g., DSF, ITC, MST, and NMR)
Design and execute research plans to ensure that critical project requirements, timelines and deliverables are met
Troubleshoot and solve scientific problems independently
Operate and maintain lab equipment independently
Investigate and implement new technologies based on scientific needs
Serve as the core biophysicist on cross-functional project teams, interpreting and communicating results in a clear and concise manner to academic and industry partners
Ability to work with large datasets and maintain organized databases.