Principal Research Associate, Bioanalytical

Vertex Inc. • Boston, MA

8d • $86,500 - $129,800 • Onsite

About The Position

Conduct bioanalytical assays to support preclinical study sample analysis. Carry out method development and optimization to quantify target proteins. Maintain proper documentation of experiments and support QC data review. Collaborate with cross-functional teams to review study design and interpret results. Prepare technical reports and presentations to document and communicate results.

Requirements

• Employer will accept a Master’s degree or equivalent, in applied science, biotechnology or a related field and 3 years of experience in the job offered or in a Principal Research Associate, Bioanalytical-related occupation.
• Perform biochemical and ligand binding assays to support sample analysis from preclinical studies including protein extraction and quantification, automated capillary western blot, ELISA, MSD and ELISPOT.
• Drive splenocyte isolation and cell culture.
• Coordinate sample storage, data analysis and interpretation using GraphPad PRISM.
• Perform assay development, optimization, and qualification according to FDA guidelines for bioanalytical method validation.
• Execute and document assays ELN with good laboratory practices and good documentation practices.
• Coordinate biodistribution, toxicology and pharmacology studies for investigational new drug application.
• Conduct biochemistry and molecular biology on CRISPR strategies for gene and cell therapies.
• Perform statistical analysis including 4PL, regression analysis, standard deviation and coefficients of variation calculations.

Responsibilities

• Conduct bioanalytical assays to support preclinical study sample analysis.
• Carry out method development and optimization to quantify target proteins.
• Maintain proper documentation of experiments and support QC data review.
• Collaborate with cross-functional teams to review study design and interpret results.
• Prepare technical reports and presentations to document and communicate results.

Benefits

• This role is eligible for an annual bonus and annual equity awards.
• Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.
• At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.
• From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Number of Employees: 1,001-5,000 employees