Principal Research Associate, Bioanalytical

Vertex Pharmaceuticals • Boston, MA

6d • $86,500 - $129,800 • Onsite

About The Position

Conduct bioanalytical assays to support preclinical study sample analysis. Carry out method development and optimization to quantify target proteins. Maintain proper documentation of experiments and support QC data review. Collaborate with cross-functional teams to review study design and interpret results. Prepare technical reports and presentations to document and communicate results.

Requirements

• Employer will accept a Master’s degree or equivalent, in applied science, biotechnology or a related field and 3 years of experience in the job offered or in a Principal Research Associate, Bioanalytical-related occupation.
• Position requires demonstrable experience in the following: Perform biochemical and ligand binding assays to support sample analysis from preclinical studies including protein extraction and quantification, automated capillary western blot, ELISA, MSD and ELISPOT.
• Drive splenocyte isolation and cell culture.
• Coordinate sample storage, data analysis and interpretation using GraphPad PRISM.
• Perform assay development, optimization, and qualification according to FDA guidelines for bioanalytical method validation.
• Execute and document assays ELN with good laboratory practices and good documentation practices.
• Coordinate biodistribution, toxicology and pharmacology studies for investigational new drug application.
• Conduct biochemistry and molecular biology on CRISPR strategies for gene and cell therapies.
• Perform statistical analysis including 4PL, regression analysis, standard deviation and coefficients of variation calculations.

Responsibilities

• Conduct bioanalytical assays to support preclinical study sample analysis.
• Carry out method development and optimization to quantify target proteins.
• Maintain proper documentation of experiments and support QC data review.
• Collaborate with cross-functional teams to review study design and interpret results.
• Prepare technical reports and presentations to document and communicate results.

Benefits

• annual bonus
• annual equity awards
• medical, dental and vision benefits
• generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• educational assistance programs including student loan repayment
• a generous commuting subsidy
• matching charitable donations
• 401(k)

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Number of Employees: 5,001-10,000 employees