Preclinical Modeling Sr. Scientist – Center of Excellence for Pediatric Immuno-Oncology

St. Jude Children's Research Hospital•Memphis, TN

1d•$104,000 - $186,160

About The Position

Conducts experiments/projects independently under overall direction of the Principal Investigator and/or more senior scientists. Designs and conducts studies to investigate specific basic science or clinical research questions within field of expertise. Develops procedures and participates in the publication of research results as necessary. The Center of Excellence for Pediatric Immuno-Oncology (CEPIO) is seeking an experienced Sr. Scientist to manage the Center’s immuno-oncology preclinical murine modeling core. CEPIO serves as the central hub to advance and coordinate cross-disciplinary studies in immuno-oncology across St. Jude basic and clinical Departments, Cores, and Centers. The successful candidate is expected to have significant prior experience in developing and standardizing preclinical murine models to support target discovery, validation, and functional testing, including the generation of new genetically engineered mouse models (GEMMs). The Sr. Scientist will play a central role in developing and managing faithful disease models in vivo (e.g., GEMMs, surgically induced murine models) to support immuno-oncology research and translational efforts. This position offers the opportunity to engage in high-impact research with translational potential, contributing directly to developing novel cancer immunotherapies. Maintaining an up-to-date knowledge of, and having a high level of enthusiasm for, new and emerging technologies in preclinical murine modelling for immuno-oncology and their potential applications will be important. This includes beta-testing new tools, customizing technologies to fit CEPIO’s research needs, and developing in-house protocols for complex experiments. The ideal candidate will work with collaborators across CEPIO with the goals of establishing faithful models to enable and support immuno-oncology research and translational efforts.

Responsibilities

Coordinate multiple aspects of research projects and execute laboratory experiments utilizing appropriate laboratory techniques, tools, and methods.
Provide inputs regarding research protocols and experiments, set up protocols, and assist in developing new laboratory techniques as required.
Identify, process, organize, summarize, review, and report relevant experimental data.
Draft sections of research manuscripts as directed.
Support monitoring and stocking of supplies, and calibration, maintenance, troubleshooting, and purchase of equipment within area.
Instruct other staff in basic laboratory techniques and procedures.
Design, troubleshoot, and refine experimental approaches to answer critical research questions.
Process, organize, and analyze complex datasets, providing detailed reports on findings.
Provide technical support for ongoing projects, including maintaining datasets, lab documentation, and compliance with safety regulations.
Engage in collaborative research projects with internal and external teams to advance research and translation in immuno-oncology.
Maintain regular and predictable attendance, contributing to a positive and productive lab environment.