Postdoctoral Scholar - High-Throughput Discovery

Lawrence Berkeley National Laboratory • Berkeley, CA

7d • Onsite

About The Position

Lawrence Berkeley National Laboratory is hiring a Postdoctoral Scholar - High-Throughput Discovery within the Molecular Foundry division. This position will accelerate the design and discovery of biological materials for binding critical minerals and materials. The postdoc will be part of a collaborative team of researchers in the Molecular Foundry from the Biological Nanostructures, Data Science and Infrastructure, Imaging and Manipulation, and Inorganic facilities. The postdoc will create microarrays of metal-binding proteins and/or peptides and develop assays for metal binding. Based on genome-wide searches, candidate proteins will be screened for targeted metal binding using fluorescence, label-free, and mass spectroscopy techniques.

Requirements

• PhD degree in Chemistry, Biochemistry, Chemical Biology, Material Science, or related areas.
• Relevant experience in protein purification, characterization, and bioconjugation.
• Familiarity with analytical instruments including but are not limited to fluorescence spectroscopy, mass spectrometry, protein purification and characterization, and 96-well plate-based assays.
• Experience with statistical design of experiments and data analysis software.
• Strong problem-solving capabilities with demonstrated ability to present novel methods and techniques to solve problems within broadly defined objectives.
• Demonstrated ability to work independently and as part of a multi-disciplinary team.
• Demonstrated strong written and oral communication skills as documented by peer-reviewed publications and seminars/presentations.

Nice To Haves

• Experience with Optical, Fluorescence or Atomic Force Microscopy.
• Experience with lab automation equipment and microarrays.
• Experience with programming languages, such as python.
• Experience with machine-learning, such as training large language models.

Responsibilities

• Work collaboratively in a fast-paced lab environment on a multi-disciplinary project supported across multiple Molecular Foundry facilities.
• Develop and design methods using automated robotics for protein expression, purification and surface conjugation on microarray substrates.
• Correlate fluorescence, label-free, mass spectroscopy, and microscopy data form a microarray platform to develop a parallel readout of protein function.
• Correlate and curate data from various instruments and methods into AI-ready format for analysis.
• Prepare and deliver data-oriented reports, manuscripts, and participate in proposal preparation, patent applications, and internal/external presentations.
• Perform work in accordance with EH&S guidelines and regulations.
• Support and contribute to the Berkeley Lab Stewardship culture.
• Provide assistance to maintain laboratory equipment and instruments.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 101-250 employees