Postdoctoral Researcher, Quantitative Systems Pharmacology - Fixed Term Contract
About The Position
The Clinical Pharmacology and Quantitative Medicine (CPQM) group in Respiratory, Immunology and Inflammation Research Unit, R&D GSK is recruiting for a Postdoctoral researcher in Quantitative Systems Pharmacology (QSP) to join their CPQM QSP team. The CPQM at GSK is a newly established organization with the remit to become a Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modelling. This industrial QSP Postdoc position represents a unique opportunity for those with PhD, MD, PharmD or equivalent doctoral background, who have previous experience in mechanistic mathematical modelling to gain pharmaceutical industry experience of applying systems modelling and computational methodologies to drug discovery and development to advance the vision and mission of GSK's rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
Requirements
- PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology
- Strong drive to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design
- Strong communication skills and demonstrated ability to work in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results
Nice To Haves
- Prior experience with applications in pharmaceutical research and development is a plus
- Prior experience in Respiratory (e.g. COPD, IPF), Renal (e.g. CKD, nephrotoxicity), Hepatology (e.g. MASH) and/or Infections diseases (e.g. HBV) is a plus
Responsibilities
- Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease, its pathways and progression as well as drug action to prevent, treat and cure diseases; and conduct simulations of virtual patients to inform target and/or asset prioritization and optimal trial design
- Develop and/or utilize state-of-the-art mathematical tools including knowledge of non-linear dynamics, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction
- Identify relevant question(s) of interest by working with disease area experts across different disciplines and address the question(s) by applying mechanistic and systems modelling
- Communicate and work in close collaboration with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker, genomics scientists and other cross-matrix colleagues to inform research and development programs and improve our understanding of disease mechanisms
- Promote transparency and communicate R&D achievements through publications in appropriate scientific journals
Benefits
- We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Industry
Chemical Manufacturing
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
