Postdoctoral Research Associate - Genetics

Washington University in St. Louis

10d • Onsite

About The Position

We invite highly motivated candidates to apply for positions as postdoctoral fellows in the laboratory of Dr. Jeff Milbrandt in the Department of Genetics at WashU in St. Louis. Our primary goal is to unravel the mechanism of axon degeneration and its role in neurodegenerative disease. Many of our projects are pursued collaboratively with the Aaron DiAntonio lab and focus on how defects in NAD homeostasis alter disease progression in peripheral neuropathy, ALS and retinal degenerative disorders. One set of studies is aimed at determining how the NADase activity of the TIR domain protein SARM1 is regulated and how its activity influences downstream signaling pathways that control axon maintenance. Another area of interest focuses on motor neuron abnormalities that occur in ALS and in peripheral neuropathy. In particular, we are interested in the unique metabolic vulnerability of motor axons and how metabolic deficits and mitochondrial dysfunction in Schwann cells contribute to motor neuron diseases. We are also pursuing studies to define the cellular composition of peripheral nerves, particularly the microglial-like cells that contribute to nerve homeostasis as well as disease progression. These projects utilize a wide breadth of technologies from single cell sequencing to mass spectrometry to high throughput, quantitative imaging. In addition, we use human genetics, AAV viral therapies, and disease models, including mutant mice and iPSC-derived neurons to further understand neurodegenerative processes. These projects are funded by multiple grants from the NIH. This opportunity requires the ability to visit St. Louis for potential interviews.

Requirements

• Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.
• No specific certification/professional license is required for this position.
• No specific work experience is required for this position.

Nice To Haves

• Ph.D. or M.D./Ph.D. in biological sciences or related field.
• Genomics
• Molecular Biology
• Neuroscience

Responsibilities

• Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.
• For more information on the lab please visit https://milbrandtlab.wustl.edu/.

Benefits

• Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees.
• Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours.
• Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

What This Job Offers

• Job Type: Full-time
• Education Level: Ph.D. or professional degree