Postdoctoral Fellow-MSH-30035-387

Mount Sinai Health System • New York, NY

4d • Onsite

About The Position

The postdoctoral fellow will lead projects funded by the BrightFocus Foundation and My Name’5 Doddie to explore the role of TDP-43 in affecting gene expression and RNA splicing in the diseases Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and Alzheimer’s Disease (AD). The projects will combine analysis of bulk tissue and single-cell transcriptomics with both short-read and long-read RNA-seq to identify rare cellular populations and rare mRNA isoforms in the spinal cord associated with ALS, the frontal cortex in FTD, and the hippocampus in AD, and assess how these cells and isoforms are associated with disease pathology, disease progression, and genetic risk factors. The candidate will have access to human patient tissues from the Mount Sinai Neuropathology Brain Bank, the Target ALS postmortem tissue collection, and the University College London Queen Square Brain Bank. The candidate will join international consortia with labs across the US and UK, and attend regular monthly virtual meetings to present progress and discuss with the other groups. The candidate will attend yearly in-person meetings to present their results to a wider audience, and meet in person with the other consortium members. The candidate will join a multidisciplinary research team that includes geneticists, computational biologists, immunologists, pathologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease within the Icahn School of Medicine at Mount Sinai. The candidate will be mentored by Dr Jack Humphrey in the Department of Neuroscience. This work could lead to a better understanding of cellular interactions in the nervous system, and how the neuronal response to specific protein pathologies shapes the course of disease. This work could lead to new biomarkers for disease progression and new therapeutic targets.

Requirements

• Single-cell/nucleus RNA-seq analysis
• Genetics of both rare and common variation
• Long-read RNA-seq
• Spatial Transcriptomics
• PhD in Neuroscience and/or computational biology with a focus on TDP-43 in ALS, FTD, or AD.
• Experience with single-cell datasets
• Experience with genetics
• Experience with RNA splicing analysis
• Experience working with TDP-43 datasets
• Experience re-analysing public datasets

Responsibilities

• The postdoctoral fellow will lead projects funded by the BrightFocus Foundation and My Name’5 Doddie to explore the role of TDP-43 in affecting gene expression and RNA splicing in the diseases Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and Alzheimer’s Disease (AD).
• The projects will combine analysis of bulk tissue and single-cell transcriptomics with both short-read and long-read RNA-seq to identify rare cellular populations and rare mRNA isoforms in the spinal cord associated with ALS, the frontal cortex in FTD, and the hippocampus in AD, and assess how these cells and isoforms are associated with disease pathology, disease progression, and genetic risk factors.
• The candidate will join international consortia with labs across the US and UK, and attend regular monthly virtual meetings to present progress and discuss with the other groups.
• The candidate will attend yearly in-person meetings to present their results to a wider audience, and meet in person with the other consortium members.
• The candidate will join a multidisciplinary research team that includes geneticists, computational biologists, immunologists, pathologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease within the Icahn School of Medicine at Mount Sinai.
• The candidate will be mentored by Dr Jack Humphrey in the Department of Neuroscience.

What This Job Offers

• Job Type: Full-time
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees