Postdoctoral Associate (Urology)

University of Miami • Miami, FL

4d

About The Position

The Department of Urology is currently seeking a full time Post Doctoral Associate to work in Miami. The Post Doctoral Associate performs scientific research and studies under the supervision of managing staff. Moreover, the Post Doctoral Associate promotes institutional recognition through literal contributions to the scientific community. Our laboratory focuses on mechanistic discovery to understand the metabolic and molecular mechanisms of androgen synthesis and androgen receptor gain-of-function that lead to resistance to hormonal therapy. Our work is revealing fundamental endocrine mechanisms in both normal physiology and disease, including stress, aging, and glucocorticoid resistance, that will lead to broad applications to oncology and cancer physiology. Specific areas include: Metabolic and genetic changes required for hormone therapy resistance in prostate and breast cancers Discovery of entirely new mechanisms of endocrine physiology and regulation Clinical validation in patients and clinical trials using innovative approaches Animal models of advanced cancer for translational and therapeutic studies Identifying targets for the development of new pharmacologic therapies Drug discovery for new therapies This position is ideal for an individual with a strong interest in rapid translation of basic mechanistic discoveries to the bedside as this is a principal goal of the Sharifi Laboratory. For example, we have shown that our discovery of a gain-of-function in a steroid-synthesizing enzyme is a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol . 2016;17:1435-44; JAMA Oncol . 2018;4:558-62; JAMA Oncol . 2020;6(4):e196496). We are currently evaluating this biomarker in an active clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development, and clinical trials.

Requirements

• Ph.D. in biochemistry, chemistry, molecular biology or another relevant field required
• Has the appropriate expertise in discovery of molecular, biochemical or chemical mechanisms; and is highly driven.
• Outstanding verbal and communication skills are required.
• Skill in collecting, organizing, and analyzing data.
• Ability to recognize, analyze, and solve a variety of problems.
• Ability to exercise sound judgment in making critical decisions.

Responsibilities

• Conducts research on specific areas of study as assigned.
• Prepares research reports and technical papers for publishing.
• Investigates the feasibility of applying a wide variety of scientific principles and theories.
• Maintains substantial knowledge of state-of-the-art principles and theories.
• Develops advanced analytical models and systems and provides solutions and analyses to support strategic and tactical decisions.
• Adheres to University and unit-level policies and procedures and safeguards University assets.

Benefits

• The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees