Post-Doctoral Research Fellow Department of Pathology & Genomic Medicine, Lab of Dr. Tykocinski

Thomas Jefferson University • Philadelphia, PA

7d

About The Position

The laboratory of Dr. Mark Tykocinski, former dean of the Sidney Kimmel Medical College of Thomas Jefferson University and recipient of the 2026 FASEB ASIP Gold-Headed Cane Award, is seeking a motivated and talented scientist to join our research team. Our laboratory focuses on the development of novel, dual-targeting fusion protein therapeutics designed to selectively activate or suppress innate and adaptive immune responses. These engineered fusion proteins, targeted to cancer and immune-related diseases, are being advanced via a direct translational pathway into clinical trials, and benefit, in part, from an active partnership with a clinical-stage biotech startup. The successful candidate will leverage training in immunology, structural biology, and molecular biology to design, execute, and analyze experiments that support ongoing and emerging research projects within the lab. Candidates with expertise in immunology and/or protein engineering and prior experience with murine tumor models are strongly preferred.

Requirements

• Ph.D., in structural biology and molecular biology
• Previous experience in an academic lab setting preferred.

Nice To Haves

• Candidates with expertise in immunology and/or protein engineering and prior experience with murine tumor models are strongly preferred.

Responsibilities

• Independently formulate hypotheses and design experiments aligned with lab objectives.
• Execute and oversee complex experimental protocols in molecular and cellular biology, protein biochemistry, and immunological assays.
• Perform mammalian cell culture using sterile technique, including maintenance and manipulation of immune and tumor cell lines.
• Conduct and interpret in vivo experiments using murine models, including tumor engraftment, treatment response monitoring, and tissue collection.
• Collect, organize, and analyze experimental data using appropriate statistical and analytical tools.
• Present findings in the form of oral presentations and written reports for internal lab meetings, grant submissions, and external conferences.
• Draft scientific manuscripts, abstracts, and grant proposals in collaboration with the lab team.
• Maintain detailed and accurate electronic records of experimental procedures, data, and protocols.
• Stay current with the scientific literature and integrate relevant findings into experimental design.
• Collaborate with lab members and external partners to advance project goals and support translational efforts.

Benefits

• Jefferson offers a comprehensive package of benefits for full-time and part-time colleagues, including medical (including prescription), supplemental insurance, dental, vision, life and AD&D insurance, short- and long-term disability, flexible spending accounts, retirement plans, tuition assistance, as well as voluntary benefits, which provide colleagues with access to group rates on insurance and discounts.
• Colleagues have access to tuition discounts at Thomas Jefferson University after one year of full time service or two years of part time service.
• All colleagues, including those who work less than part-time (including per diem colleagues, adjunct faculty, and Jeff Temps ), have access to medical (including prescription) insurance.
• For more benefits information, please click here

What This Job Offers

• Job Type: Full-time
• Education Level: Ph.D. or professional degree