Post Doctoral Position Singh Lab
About The Position
Your research will build upon ongoing efforts to analyze the molecular encoding of memory in macrophages and T cells, as well as its functional consequences for both innate and adaptive immune responses. The proposed work will leverage expertise in single-cell and single-molecule analyses, as well as utilize experimental and computational tools, the latter enabling predictions of DNA sequences that dictate memory-specific alterations in chromatin structure at single-base pair resolution. Changes in these research plans may occur and will be based on mutual discussions with Drs. Gottschalk and Singh of evolving research priorities and experimental progress.
Requirements
- Candidate must have a Ph.D. or equivalent degree in biomedical sciences.
- expertise in single-cell and transcriptomic analyses in primary immune cells.
Responsibilities
- using computational approaches to predict DNA sequence features that dictate immune memory
- experimentally investigating the underlying mechanisms
- Approaches used in this role will include assays for transposase-accessible chromatin with sequencing (ATAC-Seq)
- single-cell transcriptomic analyses
- CRISPR-mediated perturbation
- development of gene regulatory networks
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What This Job Offers
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
