The laboratory delves into the intricate mechanisms governing basal and pathological bone turnover at the Immuno-skeletal Interface. This field, known as “osteoimmunology,” explores the paradoxical role of immune cells and cytokines in driving skeletal metabolism. Our research encompasses the targeting of anergic T cells to stimulate bone formation and the utilization of costimulation inhibitors targeting CD8 T cells to enhance skeletal regeneration. Additionally, we investigate the mechanisms and functions of the microbiota underlying skeletal damage associated with HIV immunodeficiency. This includes HIV-antiretroviral therapy-induced immune reconstitution bone loss (IRBL), a severe side effect of antiretroviral drugs that severely damages the skeleton. The laboratory is currently supported by grants from both the National Institutes of Health (NIH) and the Department of Veterans Affairs (VA). The ideal applicant should possess US citizenship and a robust background in one or more of the following specialized areas:1. Comprehensive knowledge of osteoimmunology and/or bone biology.2. Expertise in fundamental skeletal phenotyping technologies, including micro-CT and quantitative bone histomorphometry.3. Proficiency in flow cytometry.4. Strong skills in mouse husbandry are essential, with additional proficiency in minor surgical procedures such as ovariectomy highly desirable.5. Familiarity with fundamental molecular and protein biochemistry techniques is advantageous.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree