Phosphoramidite Scientist - Process R&D

Veranova L P•Devens, MA

13d•$110,000 - $120,000•Onsite

About The Position

At Veranova, we believe people are our most important asset, and we are dedicated to building the most talented workforce in our industry. Our commitment to uncompromising focus on quality, compliance, safety, and excellence in delivery shapes everything we do. We are not just looking for skills; we are seeking innovative individuals who have a mindset open to learning and growth, and a desire to make a difference. Veranova is a global leader in the development and manufacturing of complex active pharmaceutical ingredients (APIs) for pharma and biotech customers. With deep technical expertise and impressive flexibility, we develop solutions and processes that support and accelerate innovation. Join us on our mission to enable current and next-generation therapeutics to improve and save the lives of patients. Role Overview: The Scientist role within the Chemical Development group will focus on the synthesis, process development, and analytical strategy for protected phosphoramidite precursors used in therapeutic oligonucleotide API manufacturing. This position is key to building Veranova’s commercial capability in producing high-quality oligonucleotide building blocks. The ideal candidate will have strong expertise in phosphoramidite chemistry, including impurity profiling and customer-specific requirements. This role will also collaborate closely with the Analytical Team to establish robust characterization and control strategies that ensure exceptional product quality.

Requirements

BS in Organic Chemistry or equivalent with 3-5 years related experience in a pharmaceutical industry, or MS in Organic Chemistry or equivalent with 0-2 years related experience in the pharmaceutical industry.
Ability to read, analyze, and interpret English-language chemical periodicals, scientific journals, and regulatory documents.
Experience with organic synthesis and process development
Experience with common analytical techniques such as HPLC, GC, NMR, UV, and LC-MS.
Experience in establishing integrated plans with defined resources and tasks.
Ability to write clear and concise technical reports.
Good understanding of Microsoft Office and statistical software.
Demonstrate ability to exercise good judgment and make decisions quickly.
Good written and verbal communication skills.
Ability to work independently and in a team environment.

Responsibilities

Develop and optimize synthetic routes for protected Phosphoramidite subunits used in therapeutic oligonucleotide API synthesis.
Identify and mitigate side reactions commonly associated with Phosphoramidite chemistry.
Define and implement specifications aligned with customer expectations for commercial-grade oligonucleotide precursors.
Provide expert guidance to the Analytical Team on the selection and application of appropriate analytical methods for product and impurity characterization, based on prior experience and industry standards.
Collaborate with cross-functional teams including Analytical Development, Quality, and Manufacturing to ensure successful scale-up and tech transfer.
Prepare technical documentation including batch records, specifications, and development reports in accordance with SOPs and cGMP guidelines.
Present scientific findings and project updates to internal stakeholders and external customers.
Support the establishment of quality and regulatory standards for commercial production of oligonucleotide precursors.
Contribute to project planning, budgeting, and timeline management for precursor development programs.
Other duties as assigned

Benefits

Health & Wellness: Comprehensive health & wellness benefits.
Access to mental health resources and wellness programs.
Generous PTO and holiday pay policies.
Financial Wellness: Veranova is committed to fair and transparent compensation practices.
This includes a competitive base salary, eligibility for performance-based bonuses, and an attractive 401(k) Plan with company match.
Salary ranges reflect the scope and expectations of the role, and are based on market data, internal equity, and role-specific factors.
Final compensation may vary depending on experience, skills, education, and business needs.
Professional Development : Opportunities for continuous learning through LinkedIn Learning, workshops, conferences, and mentorship.
Tuition Assistance for Undergraduate and Graduate degree programs.
Inclusive Culture: At Veranova, an inclusive culture is integral to our values. We welcome people with diverse experiences and perspectives who share our mission to improve and save lives. Even if you don’t meet every qualification, we encourage you to apply.
Veterans, first responders, and those transitioning from military to civilian life bring valuable skills that strengthen our team.