Nonclinical Research Intern
About The Position
Why Sarepta? Why Now? The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne. We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients. What Sarepta Offers At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. The Importance of the Role The intern will help accelerate ongoing research timelines by supporting molecular assays, data analysis, and model development. This fresh perspective and added resourcing allow the team to maintain momentum on high‑priority strategic initiatives while strengthening Sarepta’s mission to advance innovative therapies efficiently. The Opportunity to Make a Difference Explore, establish, and maintain 3D liver models or transwell culture systems that more accurately represent physiological liver environments. Perform AAV transduction experiments under both control and steatosis conditions to evaluate liver injury phenotypes. Conduct molecular assays—including ddPCR, RT‑ddPCR, and ELISA—to quantify relevant injury or mechanistic markers. Contribute to assay development and optimization for mechanistic endpoints such as: Steatosis markers Fibrosis markers Oxidative stress indicators Apoptosis markers Assist with experimental planning, sample processing, data organization, and preliminary data interpretation. Summarize experimental findings in a scientific presentation delivered to the team at the end of the internship. Maintain accurate and detailed electronic lab records in accordance with scientific and organizational standards.
Requirements
- Currently pursuing a bachelor's degree, master's degree in biology, Molecular Biology, Biochemistry, Biomedical Engineering, Pharmacology, or a related scientific discipline.
- Prior laboratory experience in cell culture or molecular biology preferred (coursework or lab rotations acceptable).
- Strong attention to detail and commitment to producing high‑quality, reproducible data.
- Ability to follow scientific protocols, ask thoughtful questions, and adapt to new experimental techniques.
- Strong communication, organization, and collaboration skills.
- Interest in therapeutic development, AAV biology, or toxicology research.
Nice To Haves
- Familiarity with assays such as PCR, ELISA, or cell‑based assays is a plus.
Responsibilities
- Explore, establish, and maintain 3D liver models or transwell culture systems that more accurately represent physiological liver environments.
- Perform AAV transduction experiments under both control and steatosis conditions to evaluate liver injury phenotypes.
- Conduct molecular assays—including ddPCR, RT‑ddPCR, and ELISA—to quantify relevant injury or mechanistic markers.
- Contribute to assay development and optimization for mechanistic endpoints such as: Steatosis markers Fibrosis markers Oxidative stress indicators Apoptosis markers
- Assist with experimental planning, sample processing, data organization, and preliminary data interpretation.
- Summarize experimental findings in a scientific presentation delivered to the team at the end of the internship.
- Maintain accurate and detailed electronic lab records in accordance with scientific and organizational standards.
Benefits
- Sarepta Therapeutics offers a competitive compensation and benefit package.
- Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
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What This Job Offers
Career Level
Intern
