Director, Nonclinical Research

Madrigal Pharmaceuticals • Conshohocken, PA

9d • $216,000 - $264,000

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. Director, Non-Clinical Research Position Summary Madrigal Pharmaceuticals is seeking an Director to provide scientific and strategic leadership for nonclinical development programs supporting metabolic dysfunction–associated steatohepatitis (MASH). This role will serve as the nonclinical development line function lead on cross-functional program teams representing toxicology and ADME for assets across different stages of development. This position requires a hands-on toxicologist who can rapidly assess existing nonclinical data, identify gaps, and design and oversee toxicology and ADME/DMPK strategies to support regulatory submissions and clinical development. This role is ideal for a toxicologist with strong industry experience who thrives in a collaborative, fast-paced environment. The level of the position will be commensurate with experience.

Requirements

• PhD (or equivalent) or Masters in Toxicology, Pharmacology, or a related scientific discipline.
• 12-15 years of relevant pharmaceutical or biotechnology industry experience in nonclinical development.
• ADME and/or DMPK experience strongly preferred.
• Late-stage small molecule development experience required
• Demonstrated experience designing and overseeing nonclinical safety and ADME studies to support INDs and clinical development.
• Experience managing outsourced studies and working effectively with CROs and external partners.
• Strong written and verbal communication skills and ability to work effectively on cross-functional teams.

Responsibilities

• Serve as the nonclinical development line function lead on program teams, representing toxicology and ADME/DMPK in cross-functional decision-making.
• Develop and execute integrated nonclinical development strategies to support IND-enabling and clinical-stage programs in MASH.
• Provide scientific oversight of CRO-conducted studies, including protocol development, study monitoring, data review, interpretation, and reporting.
• Evaluate externally generated nonclinical data from acquired programs, identifying gaps, risks, and mitigation strategies.
• Interpret toxicology, toxicokinetic, and ADME data to support clinical dose selection, safety margins, and risk assessment.
• Contribute to the preparation, review, and approval of nonclinical sections of regulatory submissions, including INDs, amendments, and briefing packages.
• Partner closely with colleagues in pharmacology, clinical development, regulatory affairs, CMC, and project management to ensure alignment of nonclinical plans with program objectives and timelines.

Benefits

• All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create.
• By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
• Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans.
• We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings.
• In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family.
• The company also provides other benefits in accordance with applicable federal, state, and local laws.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree
• Number of Employees: 501-1,000 employees