Lead Researcher OR Associate Scientist in the Babu Group

St. Jude Children's Research Hospital•Memphis, TN

9d•Onsite

About The Position

This is a Lead Researcher or Associate Scientist opportunity with the Babu Group in the Department of Structural Biology and the G Protein-Coupled Receptor (GPCR) Collaborative. As a part of the Center of Excellence for Data-Driven Discovery in the Department of Structural Biology at St. Jude Children’s Research Hospital, the Babu Group seeks a highly driven, full-time experimental Lead Researcher OR Associate Scientist with a strong background in GPCR pharmacology and signal transduction. The candidate will design and carry out high-throughput assays aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies. The G Protein Coupled Receptor (GPCR) Collaborative is a recently established national collaborative between six leading GPCR biology and pharmacology experts to reveal the molecular determinants and fidelity of GPCR signaling in health and disease. The goal of the Collaborative is to gain fundamentally new insights into GPCR physiology using state-of-the-art technologies that shift focus from time-averaged, ensemble investigations towards understanding the properties and functions of single molecules and assemblies in space and time. The Collaborative’s Aims will be accomplished by leveraging the complementary expertise of the Collaborative members: M. Madan Babu, Member, Dept. of Structural Biology, St. Jude Children’s Research Hospital Scott Blanchard, Member, Dept. of Structural Biology, St. Jude Children’s Research Hospital Georgios Skiniotis, Member, Dept. of Structural Biology, St. Jude Children’s Research Hospital Jonathan Javitch, Professor of Molecular Pharmacology and Therapeutics, Columbia University & NY State Psychiatric Institute Robert Lefkowitz, Chancellor's Distinguished Professor of Medicine, Duke University Alice Ting, Professor of Genetics, Biology, and Chemistry, Stanford University The ideal candidate will be an expert in GPCR pharmacology and will design and use biosensors to perform imaging, high-throughput screening, and functional GPCR assays in mammalian cells. This role is appropriate for a candidate holding a Master’s degree and varying degrees of experience, up to a recent PhD. Proven experience in GPCR pharmacology is required. Experience using optical plate readers, light microscopy, or flow cytometry to study GPCRs and GPCR signaling is required. This role requires an inquisitive problem-solver who thrives in a fast-paced, collaborative research group with diverse expertise. The appropriate candidate is a recent PhD/MS graduate (no more than 2 y post-PhD), independently able to propose testable hypotheses based on their understanding of the GPCR literature, and design and carry out experiments to test them. Please join us if you want to put your expertise in GPCR biology to work building high-throughput assay platforms to discover novel modulators of medically relevant GPCRs. The Babu Group uses data-driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families such as GPCRs and Kinases, respectively. The Lead Researcher will design and carry out experiments aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies. Work from our group has revealed insights into signaling mechanisms linking the ligand-binding pocket in receptors (Nature 2013, Cell 2025) to activation-dependent conformational changes (Nature 2016), the selective binding of G proteins (Nature 2017), and the allosteric activation mechanism of G proteins (Nature 2015). We have demonstrated that GPCR isoforms diversify signaling responses in different human tissues (Nature 2020) and that GPCRs are highly variable in the human population, contributing to variable drug responses and posing an economic burden on healthcare systems (Cell 2018). The Babu Group strives to build and maintain a culture of respect, diversity, and inclusion, and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.

Requirements

Bachelor’s degree in a relevant scientific area.
A recent or anticipated PhD in GPCR biology/pharmacology/biotechnology, or a Master’s plus demonstrated work experience in the GPCR field, is preferred.
Proven experience in GPCR pharmacology is required.
Experience using optical plate readers, light microscopy, or flow cytometry to study GPCRs and GPCR signaling is required.
This role requires an inquisitive problem-solver who thrives in a fast-paced, collaborative research group with diverse expertise.
The appropriate candidate is a recent PhD/MS graduate (no more than 2 y post-PhD), independently able to propose testable hypotheses based on their understanding of the GPCR literature, and design and carry out experiments to test them.

Nice To Haves

Experience leading and supporting research experiments preferred.

Responsibilities

Development of optical high-throughput assays for functional screens to dissect GPCR signaling
Using fluorescence and FRET/BRET-based reporters of GPCR signaling and ligand binding
Engineering mammalian cell lines
Performing modern cellular and molecular biology workflows
Meticulous electronic documentation of experimental observations, procedures, sample organization, and results
Collaborating with Structural Biology’s Protein Technology Center (PTC)
Planning and presenting research with passion and clarity
Contribute to the development of a working hypothesis through an in-depth literature review
Prepare high-quality manuscripts for publication in high-impact journals