CAMBRIDGE BASED ONLY)

Ring Therapeutics•Cambridge, MA

17d

About The Position

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of self-assembly nanostructures by exploiting a family of naturally occurring commensal viruses to create the first re-doseable and targetable medicines utilizing a variety of payloads, such as oligos, small molecules, and DNA. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need. Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ:MCRB), , , and Indigo Agriculture. We are seeking a highly motivated In Vivo Pharmacology Translational Scientist / Senior Principle Research Associate with an oncology background to work as part of a highly collaborative, fast paced team. The successful candidate will independently execute complex preclinical in vivo oncology studies. They will design, execute, and interpret efficacy, PK, and PD in vivo studies that drive translational decision-making across our pipeline. This role is hands-on requiring advanced technical expertise, is highly collaborative, ideal for a scientist who thrives in a dynamic startup environment and is passionate about turning data into actionable insights. You will work closely with discovery, biology, and translational teams to establish robust in vivo models, generate high-quality data, and support target validation and candidate progression.

Requirements

BSc, MSc, or PhD in Biology, Pharmacology, Biomedical Sciences, or a related discipline
Hands-on experience with in vivo models in an academic or industry setting
Strong understanding of translational biology and how in vivo data informs human disease
Experience with animal handling, dosing, imaging and necropsy procedures
Ability to independently plan experiments and troubleshoot challenges
Strong data analysis, record-keeping, and scientific communication skills

Nice To Haves

Industry experience in biotech or pharma
Experience supporting immune-oncology programs and immune modulating modalities
Hands on experience with xenograft and orthotopic tumor models in immunocompromised and humanized mouse strains
Experience with in vivo bioluminescence and fluorescence imaging is highly desirable.
Experience with GraphPad Prism for in vivo data analysis and visualization
Experience with PK/PD studies, biomarkers, or translational endpoints

Responsibilities

Design, plan, and execute complex in vivo oncology studies (including model development, efficacy, PK/PD, and mechanism-of-action studies) to support discovery and translational objectives
Develop and optimize disease-relevant animal models aligned with human biology and clinical hypotheses
Manage study execution, timelines, and logistics with minimal oversight, ensure complete, accurate and timely data capture and documentation.
Perform hands-on in vivo procedures, including tumor implantation and measurement, dosing (IP, IV IM, SC), sample collection, and tissue processing
Utilize a range of tumor models including xenograft, syngeneic and orthotopic models
Analyze, interpret, and clearly communicate in vivo data to guide project decisions
Collaborate cross-functionally with in vitro biology, bioinformatics, chemistry, and external partners
Contribute to translational strategies, biomarker identification, and hypothesis-driven study design
Maintain high standards of experimental rigor, documentation, and reproducibility
Execute all work in compliance with IACUC and institutional polices
Support CRO oversight, study planning, and data review where appropriate