Intern, Gene Delivery and Editing Process Development

Bristol Myers Squibb • Seattle, WA

22d • $23 - $42

About The Position

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . Position Summary We are seeking an enthusiastic, self-driven individual to work within the Gene Delivery and Editing Process Development team. Our team develops the end-to-end processes and technologies to deliver the critical raw materials used in the manufacturing of engineered T cells. This project will focus on the optimization of Lipid Nanoparticle (LNP) processing conditions to improve biological performance. The intern will support the formulation, downstream processing, and characterization of LNPs to address yield loss and instability, ultimately improving T-cell transfection efficiency for gene delivery programs.

Requirements

• Currently working toward BS in Biological or Chemical Engineering, Molecular or Cellular Biology, Biochemistry, or related discipline.
• 0-2 years of hands-on experience with biological laboratory procedures (ie. aseptic technique, mammalian cell culture, transfection, electroporation, ultrafiltration/diafiltration, chromatography, cryopreservation).
• Understanding of cell biology, molecular biology, and biochemistry including protein and nucleic acid structure and function.
• Ability to apply scientific principles and engineering fundamentals to solve problems.
• Familiarity with analytical techniques (e.g., PCR, flow cytometry, ELISA, HPLC, etc.).
• Understanding of statistical methods of experimental design and familiarity with DOE software (e.g. JMP, Minitab, R, etc.).
• Independently motivated with ability to multi-task, problem-solve, and coordinate activities within a team.
• Desire and drive to learn the biological mechanism of cell and gene therapy products and passion for their impact on the lives of patients with serious diseases.
• Ability to communicate clearly and concisely through oral presentation and technical writing.
• All candidates must be authorized to work in the US both at the time of hire and for the duration of their employment.
• Please note that immigration or visa sponsorship is not available for this position.
• This is a temporary, time-bound position intended for the duration of the internship or co-op program.
• Employment in this role does not imply or guarantee ongoing or permanent employment with BMS.

Responsibilities

• Design and execute hands-on experiments to formulate LNPs using microfluidic systems and optimize downstream unit operations including buffer exchange, neutralization, and clarification.
• Characterize LNP Critical Quality Attributes (CQAs)—including size, polydispersity (PDI), encapsulation efficiency, and potency—using Dynamic Light Scattering (DLS), Zeta potential, and fluorescence assays.
• Perform ex-vivo cell culture and execute cell-based assays to assess T-cell transfection efficiency and link physicochemical improvements to functional delivery performance.
• Design and analyze lab experiments using statistical Design-of-Experiments (DoE) approaches to identify conditions that improve LNP stability and recovery.
• Investigate optimal freezing and thawing conditions to preserve LNP integrity.
• Summarize and present scientific data, providing actionable insights to refine future LNP process control strategies.
• Maintain proper documentation of experiments using an electronic lab notebook and maintain a safe work environment in accordance with policies, procedures, and regulations.

Benefits

• We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
• Medical, pharmacy, dental and vision care.
• Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
• Financial well-being resources and a 401(K).
• Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
• Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
• Parental, caregiver, bereavement, and military leave.
• Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
• Other perks like tuition reimbursement and a recognition program.

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Number of Employees: 5,001-10,000 employees