Intern- Downstream Process Development

Asklepios BioPharmaceutical, Inc. (AskBio) • Durham, NC

3d • Onsite

About The Position

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people's lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need. Provide an environment for employees to reach their fullest potential. Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through. Position Summary The Downstream Process Development Intern will help to implement in-process analytical tools for AAV characterization. The project will involve comparing and correlating data generated from different analytical methods as well as streamlining data entry. This will include evaluating different assays used to quantify product titer, stability, and purity of process and drug substance samples and automating data collection. The intern will also assist in the production of recombinant AAV by learning about and assisting in the execution of various downstream unit operations. This position is located in RTP, NC and will report to a Senior Research Associate, Process Development.

Requirements

• Pursuing at least a BS degree in scientific or engineering related field
• Must be at least a Junior in university at the time of your application
• Basic understanding of downstream purification techniques (e.g. lysis, chromatography, filtration, fill/finish)
• Basic understanding of analytical methods used to characterize AAV (SEC-HPLC, ELISA, qPCR, DLS etc.)
• Proficient with MS Office Suite and ability to learn new platforms quickly (JMP statistical software)
• Strong sense of accountability and ability to prioritize multiple tasks
• Excellent organizational skills and attention to detail
• Proactive and solution-driven mindset
• Strong sense of accountability and ability to prioritize multiple tasks
• Excellent organizational skills and attention to detail
• Flexible and willing to support a variety of tasks for the downstream PD team
• Available to work full-time at the office during the summer months (May-August) at an AskBio office

Nice To Haves

• Students pursuing a Master’s degree in a scientific or engineering field are encouraged to apply
• Experience analyzing and interpreting data from assays characterizing biopharmaceutical products.
• Prior internship, work, or volunteer/extracurricular experience in the biopharma industry
• Prior experience working in a lab environment
• Prior hands-on experience in biomanufacturing
• Advanced experience with Excel/VBA scripting

Responsibilities

• Support the downstream process development team in the execution of experiments and purification of recombinant AAV
• Learn about various downstream unit operations and analytical assays used for product characterization
• Participate in an individual project to implement in-house analytical tools
• Communicate findings with other lab members
• Develop tools to streamline input and analysis of data
• Present results in a final formal presentation to the process development group

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Number of Employees: 501-1,000 employees